Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 866627..867255 Replicon chromosome
Accession NZ_CP054923
Organism Verrucosispora sp. NA02020

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUT12_RS03610 Protein ID WP_176092468.1
Coordinates 866627..867010 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HUT12_RS03615 Protein ID WP_131056284.1
Coordinates 867007..867255 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT12_RS03585 861649..863496 - 1848 WP_131052014.1 2-oxoacid:acceptor oxidoreductase subunit alpha -
HUT12_RS03590 863825..864202 + 378 WP_131052015.1 NADH-quinone oxidoreductase subunit A -
HUT12_RS03595 864209..865078 - 870 WP_176092466.1 dihydropteroate synthase -
HUT12_RS03600 865223..865582 + 360 Protein_705 DivIVA domain-containing protein -
HUT12_RS03605 866002..866499 + 498 WP_176092467.1 SRPBCC family protein -
HUT12_RS03610 866627..867010 - 384 WP_176092468.1 PIN domain-containing protein Toxin
HUT12_RS03615 867007..867255 - 249 WP_131056284.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HUT12_RS03620 867394..867984 + 591 WP_176092469.1 DNA-3-methyladenine glycosylase I -
HUT12_RS03625 867989..868612 + 624 WP_131056288.1 hypothetical protein -
HUT12_RS03630 868623..869414 - 792 WP_176092470.1 enoyl-CoA hydratase/isomerase family protein -
HUT12_RS03635 869411..870235 - 825 WP_131056292.1 PaaX family transcriptional regulator -
HUT12_RS03640 870427..870594 + 168 WP_013283866.1 DUF3117 domain-containing protein -
HUT12_RS03645 870737..872203 + 1467 WP_176092471.1 leucyl aminopeptidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(21-111)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13633.75 Da        Isoelectric Point: 5.6327

>T160631 WP_176092468.1 NZ_CP054923:c867010-866627 [Verrucosispora sp. NA02020]
VSRGILDTSILIATDVTPIPGELAISIASLAELQFGVLVAKTAEARALRLARLSAIQRRFDPLPIDEVIADSYARLAARV
VETGRQPRARVMDLLIAATAHAHDAAVYTRNAEDLAGLEDLITIHTI

Download         Length: 384 bp

>T160631 NZ_CP070598:359990-360358 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9166.20 Da        Isoelectric Point: 4.4287

>AT160631 WP_131056284.1 NZ_CP054923:c867255-867007 [Verrucosispora sp. NA02020]
MHEVGLREMRQNASDLVRRAQAGERVTITVAGRPAAVLGPVSPRTWREWDDLAGVFDQPTDPGWAGDRDLLDDAITDPWV
ER

Download         Length: 249 bp

>AT160631 NZ_CP070598:359772-359993 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References