Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 3643746..3644287 Replicon chromosome
Accession NZ_CP054919
Organism Kitasatospora sp. NA04385

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HUT16_RS16110 Protein ID WP_176188862.1
Coordinates 3644021..3644287 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HUT16_RS16105 Protein ID WP_176188861.1
Coordinates 3643746..3644024 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT16_RS16090 3640417..3640854 - 438 WP_176188858.1 GNAT family N-acetyltransferase -
HUT16_RS16095 3641263..3642813 + 1551 WP_176188859.1 hypothetical protein -
HUT16_RS16100 3643149..3643712 + 564 WP_176188860.1 SMI1/KNR4 family protein -
HUT16_RS16105 3643746..3644024 + 279 WP_176188861.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HUT16_RS16110 3644021..3644287 + 267 WP_176188862.1 Txe/YoeB family addiction module toxin Toxin
HUT16_RS16115 3644796..3645163 + 368 Protein_3173 hypothetical protein -
HUT16_RS16120 3645188..3645571 - 384 WP_176188863.1 MerR family transcriptional regulator -
HUT16_RS16125 3645722..3646387 + 666 WP_176188864.1 class II aldolase/adducin family protein -
HUT16_RS16130 3646384..3646788 + 405 WP_176188865.1 carboxymuconolactone decarboxylase family protein -
HUT16_RS16135 3647097..3647318 - 222 WP_176188866.1 hypothetical protein -
HUT16_RS16140 3647765..3647968 + 204 WP_030916923.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10446.87 Da        Isoelectric Point: 8.4928

>T160630 WP_176188862.1 NZ_CP054919:3644021-3644287 [Kitasatospora sp. NA04385]
VKIQFTDGGWADYLYWQANDRRLLKRINQLIEDIRRNGHEGIGKPEPLRHELAGAWSRRIDQEHRLVYVLDEPANTVCII
ACRYHYSK

Download         Length: 267 bp

>T160630 NZ_CP070596:30331-30681 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10346.47 Da        Isoelectric Point: 4.2794

>AT160630 WP_176188861.1 NZ_CP054919:3643746-3644024 [Kitasatospora sp. NA04385]
MKTMSATELRSNLAAALDSVEDDAEELIITRAGHEPLVVVSLAEYASLRETDYLLRSPANAEHLRQSLRDYREGRMQSRE
LIDPEDVTEQSA

Download         Length: 279 bp

>AT160630 NZ_CP070596:30686-30988 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References