Detailed information of TA system TA160629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1147106..1147651
• Replicon: chromosome
• Accession: NZ_CP054919
• Organism: Kitasatospora sp. NA04385

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUT16_RS05080
• Protein ID: WP_176185858.1
• Coordinates: 1147106..1147387 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HUT16_RS05085
• Protein ID: WP_176192497.1
• Coordinates: 1147394..1147651 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUT16_RS05060	1142422..1143468	+	1047	WP_176185854.1	polysaccharide deacetylase family protein	-
HUT16_RS05065	1143638..1145278	-	1641	WP_176192495.1	response regulator transcription factor	-
HUT16_RS05070	1145820..1146347	+	528	WP_176185856.1	lipocalin family protein	-
HUT16_RS05075	1146436..1147035	+	600	WP_176192496.1	RNA 2',3'-cyclic phosphodiesterase	-
HUT16_RS05080	1147106..1147387	-	282	WP_176185858.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUT16_RS05085	1147394..1147651	-	258	WP_176192497.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HUT16_RS05090	1147724..1147933	-	210	WP_176185860.1	hypothetical protein	-
HUT16_RS05095	1148172..1150289	+	2118	WP_176185862.1	cellulose binding domain-containing protein	-
HUT16_RS05100	1150480..1150974	+	495	WP_176185864.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-52)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10615.25 Da
• Isoelectric Point: 11.5023

>T160629 WP_176185858.1 NZ_CP054919:c1147387-1147106 [Kitasatospora sp. NA04385]
VGRVTRFTPRAQRDLLKIERSDTLRILRRLAELQRAMDAGDTTAFDVKALRGHDARWRLGVGDHRVVCAVENGQLIVWVL
GVGHRSEVYRQLP

Nucleotide

• Length: 282 bp

>T160629 NZ_CP070595:c98322-97840 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9661.72 Da
• Isoelectric Point: 4.3359

>AT160629 WP_176192497.1 NZ_CP054919:c1147651-1147394 [Kitasatospora sp. NA04385]
MAEVRSHLADVIDRARREETPTIITRRGRQEAVVIDIEEYQRLRRIADAAEEEWLNGLADESEAEGLQGSVSLEEMAALL
RNREG

Nucleotide

• Length: 258 bp

>AT160629 NZ_CP070595:c98576-98310 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA