Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4203351..4204005 Replicon chromosome
Accession NZ_CP054913
Organism Shigella flexneri strain FDAARGOS_691

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag FOB99_RS21015 Protein ID WP_000244767.1
Coordinates 4203351..4203758 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag FOB99_RS21020 Protein ID WP_000354044.1
Coordinates 4203739..4204005 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB99_RS20995 4199308..4201041 - 1734 WP_175868077.1 single-stranded-DNA-specific exonuclease RecJ -
FOB99_RS21000 4201047..4201757 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOB99_RS21005 4201782..4202678 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
FOB99_RS21010 4202790..4203311 + 522 WP_001055867.1 flavodoxin FldB -
FOB99_RS21015 4203351..4203758 - 408 WP_000244767.1 protein YgfX Toxin
FOB99_RS21020 4203739..4204005 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
FOB99_RS21025 4204248..4205228 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
FOB99_RS21030 4205424..4206083 - 660 WP_000250274.1 hemolysin III family protein -
FOB99_RS21035 4206247..4206557 - 311 Protein_4081 ASCH domain-containing protein -
FOB99_RS21040 4206602..4208035 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
FOB99_RS21045 4208092..4208835 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T160626 WP_000244767.1 NZ_CP054913:c4203758-4203351 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T160626 NZ_CP070593:c4427581-4427474 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT160626 WP_000354044.1 NZ_CP054913:c4204005-4203739 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT160626 NZ_CP070593:4427630-4427695 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References