160607

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1619241..1619858 Replicon chromosome
Accession NZ_CP054912
Organism Pantoea ananatis strain FDAARGOS_680

Toxin (Protein)


Gene name Hha Uniprot ID D4GLR0
Locus tag FOB88_RS10625 Protein ID WP_013024903.1
Coordinates 1619643..1619858 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8A4KA49
Locus tag FOB88_RS10620 Protein ID WP_015700827.1
Coordinates 1619241..1619618 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB88_RS10590 1615527..1615781 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
FOB88_RS10595 1615793..1615933 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
FOB88_RS10600 1615992..1616870 - 879 WP_013024908.1 metal ABC transporter substrate-binding protein -
FOB88_RS10605 1616883..1617722 - 840 WP_013024907.1 metal ABC transporter permease -
FOB88_RS10610 1617719..1618387 - 669 WP_176018083.1 ABC transporter ATP-binding protein -
FOB88_RS10615 1618741..1619094 + 354 WP_110286421.1 hypothetical protein -
FOB88_RS10620 1619241..1619618 + 378 WP_015700827.1 Hha toxicity modulator TomB Antitoxin
FOB88_RS10625 1619643..1619858 + 216 WP_013024903.1 hemolysin expression modulator Hha Toxin
FOB88_RS10635 1620256..1620567 + 312 WP_176018084.1 MGMT family protein -
FOB88_RS10640 1620616..1621173 - 558 WP_176018085.1 YbaY family lipoprotein -
FOB88_RS10645 1621366..1622229 + 864 WP_176018086.1 acyl-CoA thioesterase II -
FOB88_RS10650 1622276..1623565 - 1290 WP_014606435.1 ammonium transporter AmtB -
FOB88_RS10655 1623599..1623937 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8552.98 Da        Isoelectric Point: 9.4825

>T160607 WP_013024903.1 NZ_CP054912:1619643-1619858 [Pantoea ananatis]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T160607 NZ_CP070593:379436-379813 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14722.35 Da        Isoelectric Point: 4.3976

>AT160607 WP_015700827.1 NZ_CP054912:1619241-1619618 [Pantoea ananatis]
MDEYSPKRHDIAQLKYLCENLFDDSMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT160607 NZ_CP070593:378978-379346 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References