Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 96822..98448 Replicon plasmid unnamed3
Accession NZ_CP054911
Organism Pantoea ananatis strain FDAARGOS_680

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FOB88_RS02260 Protein ID WP_176017381.1
Coordinates 97123..98448 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FOB88_RS02255 Protein ID WP_176017380.1
Coordinates 96822..97118 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB88_RS02235 92236..92607 - 372 WP_176017376.1 hypothetical protein -
FOB88_RS02245 94038..94487 + 450 WP_176017378.1 hypothetical protein -
FOB88_RS02250 95581..96618 + 1038 WP_176017379.1 tyrosine-type recombinase/integrase -
FOB88_RS02255 96822..97118 + 297 WP_176017380.1 helix-turn-helix transcriptional regulator Antitoxin
FOB88_RS02260 97123..98448 + 1326 WP_176017381.1 type II toxin-antitoxin system HipA family toxin Toxin
FOB88_RS02265 98608..98799 - 192 Protein_96 transposase -
FOB88_RS02270 98915..100026 + 1112 WP_176017382.1 IS3 family transposase -
FOB88_RS02275 100476..101465 - 990 WP_176017383.1 ParB/RepB/Spo0J family partition protein -
FOB88_RS02280 101462..102670 - 1209 WP_104933885.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fliC 1..218767 218767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50053.36 Da        Isoelectric Point: 7.4625

>T160594 WP_176017381.1 NZ_CP054911:97123-98448 [Pantoea ananatis]
MNRRQQPLSIWMNGIRVGFWEKHRGEDSLRYLPEWCADEQGRSLSLSLPFTPGNQVWRGGVVRDYFDNLLPDSEGIRRRL
AMRYGAESLEPFDLLSELGRDCVGAIQLLRADEEPTGLYSVKYRLLSESEIATTLRNTTNAALPGRQDDLGDLRLSIAGA
QEKTALLWHDEHWCIPEAHTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSKLLENFGIPVASTHIAQFEEQKALVVERF
DRKWSANRQWLIRIPQEDMCQALGVSPLRKYQVDGGPGISQIMEILSHSDQAGLDRLRFFSAQIIFWLIAATDGHAKNFS
IVSGPQGSYRLTPLYDVLSAWPVIGGGNNQIALQKCKLAMAVRGSSNYYHIGRIQRRHWIKHGELTGLSKQQIEKMMEEI
TLRTPEVIERVSNLLPQAFPQVLAEKIFEGMRYQCRLLIGK

Download         Length: 1326 bp

>T160594 NZ_CP070586:699793-700170 [Klebsiella pneumoniae]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11094.67 Da        Isoelectric Point: 8.4697

>AT160594 WP_176017380.1 NZ_CP054911:96822-97118 [Pantoea ananatis]
MKNFYTVKTLSQLRPLLIAFRKEKGLTQKDISERLGVTQQTYARMEANPASAGIERLYRVLTLLGVEINLSSEASSSDVE
RMEETTSLSDSPARLEKW

Download         Length: 297 bp

>AT160594 NZ_CP070586:699416-699742 [Klebsiella pneumoniae]
ATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTTTGGCGCACGGCTGGTACAGGCGGGCAACCGTCT
GCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACGCTGATTTACGGTATCTCGACCAGGCATTTCCAC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCTGCCATCAGCACTGTGTCACGCTCTATGCA
AAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGTATACCTGGCGATTTATCCGACACCAGCGGCAAC
CGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References