Detailed information of TA system TA160592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 5421..6046
• Replicon: plasmid unnamed2
• Accession: NZ_CP054910
• Organism: Pantoea ananatis strain FDAARGOS_680

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOB88_RS01335
• Protein ID: WP_139569196.1
• Coordinates: 5421..5819 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOB88_RS01340
• Protein ID: WP_078004800.1
• Coordinates: 5819..6046 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB88_RS01325	2494..3024	+	531	WP_176017248.1	hypothetical protein	-
FOB88_RS01330	3190..5412	+	2223	WP_176017249.1	type IV conjugative transfer system coupling protein TraD	-
FOB88_RS01335	5421..5819	-	399	WP_139569196.1	tRNA(fMet)-specific endonuclease VapC	Toxin
FOB88_RS01340	5819..6046	-	228	WP_078004800.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..91129	91129

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14996.30 Da
• Isoelectric Point: 7.7785

>T160592 WP_139569196.1 NZ_CP054910:c5819-5421 [Pantoea ananatis]
MLKFMLDTNICIFTIKNKPEHVRERFNLNTSRMCISSVTLMELIYGAEKSQAPERNLAVVEGFVSRLEVLDYDTQAAIHS
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRTEDWC

Nucleotide

• Length: 399 bp

>T160592 NZ_CP070586:365953-366321 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATGTGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCTTGGATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8521.50 Da
• Isoelectric Point: 4.7469

>AT160592 WP_078004800.1 NZ_CP054910:c6046-5819 [Pantoea ananatis]
MHTTLFLSNRTQAVRLPKSISFPEDVKHVEVIAVGRSRLITPAGESWDSWFDGEGVSADFMNVREQPTEQEREGF

Nucleotide

• Length: 228 bp

>AT160592 NZ_CP070586:365735-365956 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA