Detailed information of TA system TA160591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 97529..98436
• Replicon: plasmid unnamed1
• Accession: NZ_CP054909
• Organism: Pantoea ananatis strain FDAARGOS_680

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FOB88_RS00455
• Protein ID: WP_176017156.1
• Coordinates: 97969..98436 (+)
• Length: 156 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A8A4JZ23
• Locus tag: FOB88_RS00450
• Protein ID: WP_014598335.1
• Coordinates: 97529..97972 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB88_RS00420	92653..93039	-	387	WP_176017154.1	pyrimidine utilization protein C	-
FOB88_RS00425	93065..93817	-	753	WP_014604633.1	pyrimidine utilization protein B	-
FOB88_RS00430	93814..94905	-	1092	WP_013027866.1	pyrimidine utilization protein A	-
FOB88_RS00435	95304..95993	+	690	WP_014598333.1	HTH-type transcriptional regulator RutR	-
FOB88_RS00440	96069..96764	-	696	WP_176017155.1	hypothetical protein	-
FOB88_RS00445	96918..97142	-	225	WP_013027863.1	KTSC domain-containing protein	-
FOB88_RS00450	97529..97972	+	444	WP_014598335.1	DUF2384 domain-containing protein	Antitoxin
FOB88_RS00455	97969..98436	+	468	WP_176017156.1	RES family NAD+ phosphorylase	Toxin
FOB88_RS00460	99081..100475	+	1395	WP_014333136.1	flagellar filament capping protein FliD	-
FOB88_RS00465	101160..102095	+	936	WP_013027859.1	hypothetical protein	-
FOB88_RS00470	102157..102729	-	573	WP_176017240.1	NAD(P)H-dependent oxidoreductase	-
FOB88_RS00475	102817..103050	+	234	WP_176017157.1	DUF333 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	fliC	1..283516	283516

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-145)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (31-89)

Sequences

Toxin

Protein

• Length: 156 a.a.
• Molecular weight: 17235.75 Da
• Isoelectric Point: 5.1570

>T160591 WP_176017156.1 NZ_CP054909:97969-98436 [Pantoea ananatis]
MKLYRMTKTRYLGSAWSGFGAREGGGRWNSVGVSMVYASETASLTMLETLIHLQSASVLDFFTLMSIDVPDRLIEWIDIK
QLPDDWAAPEAPAALRLFGDAWIQSGGSVALRVPSVLSPVESNYLLNPEHPEFSAIVRQAVNIPFLFDARFSRQV

Nucleotide

• Length: 468 bp

>T160591 NZ_CP070586:239357-239842 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16375.69 Da
• Isoelectric Point: 7.0208

>AT160591 WP_014598335.1 NZ_CP054909:97529-97972 [Pantoea ananatis]
MKQFTLPVSAAEPDRLWQFAGLSSADGVMLMDQIDDGLDGTVASRIVTWAQISQAELRRMTGIAGSTFTRGVKSRFTAEQ
SERLVRFIRVMDRAVELFEGDKEKARQWLNEPARALGNKKPADLVASETGAYEVLKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT160591 NZ_CP070586:239103-239369 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA