160589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 5262271..5263323 Replicon chromosome
Accession NZ_CP054880
Organism Pseudomonas sp. 43A

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag HUW52_RS22975 Protein ID WP_026000781.1
Coordinates 5262820..5263323 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag HUW52_RS22970 Protein ID WP_175554979.1
Coordinates 5262271..5262738 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW52_RS22945 5257788..5258786 + 999 WP_016987500.1 sulfate ABC transporter substrate-binding protein -
HUW52_RS22950 5259029..5259649 - 621 WP_175554978.1 hypothetical protein -
HUW52_RS22955 5259893..5261080 + 1188 WP_016987498.1 MFS transporter -
HUW52_RS22960 5261147..5261551 - 405 WP_016987497.1 type II toxin-antitoxin system HicB family antitoxin -
HUW52_RS22965 5261551..5261763 - 213 WP_016987496.1 type II toxin-antitoxin system HicA family toxin -
HUW52_RS22970 5262271..5262738 + 468 WP_175554979.1 helix-turn-helix domain-containing protein Antitoxin
HUW52_RS22975 5262820..5263323 + 504 WP_026000781.1 PIN domain-containing protein Toxin
HUW52_RS22980 5263380..5263784 - 405 WP_016987493.1 hypothetical protein -
HUW52_RS22985 5263810..5265012 - 1203 WP_175554980.1 c-type cytochrome biogenesis protein CcmI -
HUW52_RS22990 5265009..5265479 - 471 WP_175554981.1 cytochrome c-type biogenesis protein CcmH -
HUW52_RS22995 5265476..5266012 - 537 WP_007919961.1 DsbE family thiol:disulfide interchange protein -
HUW52_RS23000 5266009..5267997 - 1989 WP_175554982.1 heme lyase CcmF/NrfE family subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-91)

Antitoxin

SinI-like, DNA-binding domain

(84-130)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 19012.72 Da        Isoelectric Point: 6.1005

>T160589 WP_026000781.1 NZ_CP054880:5262820-5263323 [Pseudomonas sp. 43A]
MWLALSGRFRARWSKEIHSEWKRNLLKNRTDLTMEQLDRTSELMDRAIPEACVCDYEELVNGLSLPDQDDRHVLAAAIRC
GAGVIVTFNLKDFPDTQLAPFGFEAQHPDEFVENLFHLNSAAVVAAAQKQRKQLKTPAMDVESFLRLLQRQGLTQSVQAL
EGYRAIL

Download         Length: 504 bp

>T160589 NZ_CP070581:86751-87056 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17275.76 Da        Isoelectric Point: 6.3819

>AT160589 WP_175554979.1 NZ_CP054880:5262271-5262738 [Pseudomonas sp. 43A]
MSIVIHPPVTLPVEREIKAAIEGQRALAAYLATQFETQHIQIFDEQNEAHRVELPTSALRLLADILAALAEGNAVKVVPV
HAELTTQEAADLLNVSRPHMIKLLESGEISYHKTGKHRRVRFADLMDYKTRRDSASEQAMALLAEQAQALRTGYE

Download         Length: 468 bp

>AT160589 NZ_CP070581:86531-86749 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References