Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5261147..5261763 Replicon chromosome
Accession NZ_CP054880
Organism Pseudomonas sp. 43A

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H8GQU6
Locus tag HUW52_RS22965 Protein ID WP_016987496.1
Coordinates 5261551..5261763 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7H8GRK7
Locus tag HUW52_RS22960 Protein ID WP_016987497.1
Coordinates 5261147..5261551 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW52_RS22940 5256859..5257683 + 825 WP_038363916.1 ion transporter -
HUW52_RS22945 5257788..5258786 + 999 WP_016987500.1 sulfate ABC transporter substrate-binding protein -
HUW52_RS22950 5259029..5259649 - 621 WP_175554978.1 hypothetical protein -
HUW52_RS22955 5259893..5261080 + 1188 WP_016987498.1 MFS transporter -
HUW52_RS22960 5261147..5261551 - 405 WP_016987497.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUW52_RS22965 5261551..5261763 - 213 WP_016987496.1 type II toxin-antitoxin system HicA family toxin Toxin
HUW52_RS22970 5262271..5262738 + 468 WP_175554979.1 helix-turn-helix domain-containing protein -
HUW52_RS22975 5262820..5263323 + 504 WP_026000781.1 PIN domain-containing protein -
HUW52_RS22980 5263380..5263784 - 405 WP_016987493.1 hypothetical protein -
HUW52_RS22985 5263810..5265012 - 1203 WP_175554980.1 c-type cytochrome biogenesis protein CcmI -
HUW52_RS22990 5265009..5265479 - 471 WP_175554981.1 cytochrome c-type biogenesis protein CcmH -
HUW52_RS22995 5265476..5266012 - 537 WP_007919961.1 DsbE family thiol:disulfide interchange protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8059.19 Da        Isoelectric Point: 10.1831

>T160588 WP_016987496.1 NZ_CP054880:c5261763-5261551 [Pseudomonas sp. 43A]
VQSRQLIKELEEAGWVLDRVTGSHHIFRHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYNPPASYEGDP

Download         Length: 213 bp

>T160588 NZ_CP070580:46414-46830 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14788.77 Da        Isoelectric Point: 4.4687

>AT160588 WP_016987497.1 NZ_CP054880:c5261551-5261147 [Pseudomonas sp. 43A]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYKAAVEVAHIMLQEIAADGESIPMPTSASAHRSNPDFANMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT160588 NZ_CP070580:46187-46417 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8GQU6

Antitoxin

Source ID Structure
AlphaFold DB A0A7H8GRK7

References