Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1189039..1189564 Replicon chromosome
Accession NZ_CP054880
Organism Pseudomonas sp. 43A

Toxin (Protein)


Gene name relE Uniprot ID A0A7H8GF58
Locus tag HUW52_RS05205 Protein ID WP_016984129.1
Coordinates 1189039..1189335 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R7UU95
Locus tag HUW52_RS05210 Protein ID WP_016984130.1
Coordinates 1189325..1189564 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW52_RS05195 1186549..1188168 + 1620 WP_175553118.1 DUF2300 domain-containing protein -
HUW52_RS05200 1188172..1188984 + 813 WP_175553119.1 DUF2135 domain-containing protein -
HUW52_RS05205 1189039..1189335 - 297 WP_016984129.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUW52_RS05210 1189325..1189564 - 240 WP_016984130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUW52_RS05215 1190006..1190752 - 747 WP_016984131.1 helix-turn-helix transcriptional regulator -
HUW52_RS05220 1190976..1191503 - 528 WP_003205933.1 inorganic diphosphatase -
HUW52_RS05225 1191616..1192428 - 813 WP_175553120.1 zinc-dependent peptidase -
HUW52_RS05230 1192433..1193083 - 651 WP_034153744.1 DedA family protein -
HUW52_RS05235 1193313..1193774 - 462 WP_007910890.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-62)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11651.55 Da        Isoelectric Point: 9.6908

>T160585 WP_016984129.1 NZ_CP054880:c1189335-1189039 [Pseudomonas sp. 43A]
MTYNLEFDRRALKEWNKLGDTVRHQFKKKLTEVLENPRIEANRLRELPDCYKVKLKSAGYRLIYQVLDQEIVVFVIAIGK
REREAAYEVAQDRLSLLP

Download         Length: 297 bp

>T160585 NZ_CP070579:c4545850-4545365 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8865.24 Da        Isoelectric Point: 4.6017

>AT160585 WP_016984130.1 NZ_CP054880:c1189564-1189325 [Pseudomonas sp. 43A]
MASINIRIDDDLKQRSFAELEKLGVTPSELLRQTLQYVAERGKLPFKAALLSEEDEVLIAVVTERLAAPQRVKVSLDDL

Download         Length: 240 bp

>AT160585 NZ_CP070579:c4546140-4545847 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8GF58

Antitoxin

Source ID Structure
AlphaFold DB A0A4R7UU95

References