Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 538671..539314 Replicon chromosome
Accession NZ_CP054880
Organism Pseudomonas sp. 43A

Toxin (Protein)


Gene name hicA Uniprot ID A0A4R7VCK5
Locus tag HUW52_RS02325 Protein ID WP_026000492.1
Coordinates 538671..538853 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Z2MDY9
Locus tag HUW52_RS02330 Protein ID WP_049802102.1
Coordinates 538913..539314 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW52_RS02310 534529..535455 + 927 WP_016983653.1 serine acetyltransferase -
HUW52_RS02315 536040..538001 + 1962 WP_171057266.1 choline transporter BetT -
HUW52_RS02320 538027..538287 - 261 WP_175552873.1 hypothetical protein -
HUW52_RS02325 538671..538853 + 183 WP_026000492.1 type II toxin-antitoxin system HicA family toxin Toxin
HUW52_RS02330 538913..539314 + 402 WP_049802102.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUW52_RS02335 539320..540357 - 1038 WP_016983657.1 LacI family DNA-binding transcriptional regulator -
HUW52_RS02340 540563..542788 + 2226 WP_175552874.1 TonB-dependent receptor -
HUW52_RS02345 542790..544109 + 1320 WP_175552875.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6903.02 Da        Isoelectric Point: 10.5417

>T160584 WP_026000492.1 NZ_CP054880:538671-538853 [Pseudomonas sp. 43A]
MRSREMIRMIEDDGWYLVAVKGSHHQYKHPHKPGRVTIKHPDSDLPKGTINSILKQAGLK

Download         Length: 183 bp

>T160584 NZ_CP070579:c4412787-4412377 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14668.46 Da        Isoelectric Point: 4.4631

>AT160584 WP_049802102.1 NZ_CP054880:538913-539314 [Pseudomonas sp. 43A]
MKFPVVLHKDADSDYGVIIPDVPGCFSAGTTVAEAFENTQEALALHYEGLVADSAPLPQVRDIDAHLDNPDYAGGIWGVV
DFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYRSRSGFLAAAALRELSV

Download         Length: 402 bp

>AT160584 NZ_CP070579:c4413034-4412768 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R7VCK5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z2MDY9

References