Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2140709..2141223 Replicon chromosome
Accession NZ_CP054876
Organism Staphylococcus aureus strain Dresden-275757

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HUW54_RS10640 Protein ID WP_000581792.1
Coordinates 2140709..2140918 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HUW54_RS10645 Protein ID WP_000138932.1
Coordinates 2140930..2141223 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW54_RS10620 2136217..2137575 - 1359 WP_000611480.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
HUW54_RS10625 2137590..2138660 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
HUW54_RS10630 2138978..2140180 + 1203 WP_001109939.1 rod shape-determining protein RodA -
HUW54_RS10635 2140444..2140581 - 138 WP_000828354.1 hypothetical protein -
HUW54_RS10640 2140709..2140918 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HUW54_RS10645 2140930..2141223 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HUW54_RS10650 2141389..2142873 + 1485 WP_000571549.1 cardiolipin synthase -
HUW54_RS10655 2142901..2143548 + 648 WP_001187630.1 HD domain-containing protein -
HUW54_RS10660 2144014..2144886 - 873 WP_000725802.1 membrane protein insertase YidC -
HUW54_RS10665 2144972..2145613 - 642 WP_175528733.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T160577 WP_000581792.1 NZ_CP054876:c2140918-2140709 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T160577 NZ_CP070579:44608-44991 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT160577 WP_000138932.1 NZ_CP054876:c2141223-2140930 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT160577 NZ_CP070579:44366-44608 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References