Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1550149..1550946 Replicon chromosome
Accession NZ_CP054876
Organism Staphylococcus aureus strain Dresden-275757

Toxin (Protein)


Gene name - Uniprot ID A0A641AAS6
Locus tag HUW54_RS07460 Protein ID WP_000525006.1
Coordinates 1550485..1550946 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HUW54_RS07455 Protein ID WP_001260486.1
Coordinates 1550149..1550472 (+) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW54_RS07405 1545884..1546441 - 558 WP_175528724.1 DUF2815 family protein -
HUW54_RS07410 1546467..1547633 - 1167 WP_000762551.1 DUF2800 domain-containing protein -
HUW54_RS07415 1547630..1547992 - 363 WP_000279446.1 hypothetical protein -
HUW54_RS07420 1548007..1548330 - 324 WP_000175000.1 hypothetical protein -
HUW54_RS07425 1548410..1548571 - 162 WP_001285955.1 DUF1270 family protein -
HUW54_RS07430 1548584..1548847 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
HUW54_RS07435 1548872..1549087 - 216 WP_001036301.1 hypothetical protein -
HUW54_RS07440 1549142..1549507 + 366 WP_001128433.1 hypothetical protein -
HUW54_RS07445 1549476..1549721 - 246 WP_001025401.1 DUF2829 domain-containing protein -
HUW54_RS07450 1549737..1549985 - 249 WP_000272861.1 helix-turn-helix domain-containing protein -
HUW54_RS07455 1550149..1550472 + 324 WP_001260486.1 helix-turn-helix domain-containing protein Antitoxin
HUW54_RS07460 1550485..1550946 + 462 WP_000525006.1 hypothetical protein Toxin
HUW54_RS07465 1550963..1551397 + 435 WP_175528725.1 hypothetical protein -
HUW54_RS07470 1551426..1551821 + 396 WP_000449655.1 hypothetical protein -
HUW54_RS07475 1551911..1552057 + 147 WP_001013104.1 hypothetical protein -
HUW54_RS07480 1552054..1552668 - 615 WP_000191459.1 hypothetical protein -
HUW54_RS07485 1552794..1554000 + 1207 Protein_1467 site-specific integrase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 1502891..1571643 68752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(8-65)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 18118.47 Da        Isoelectric Point: 4.6915

>T160570 WP_000525006.1 NZ_CP054876:1550485-1550946 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Download         Length: 462 bp

>T160570 NZ_CP070572:3878099-3878485 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12427.10 Da        Isoelectric Point: 9.3811

>AT160570 WP_001260486.1 NZ_CP054876:1550149-1550472 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT160570 NZ_CP070572:3878478-3878798 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A641AAS6


Antitoxin

Source ID Structure

References