Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 852189..852666 Replicon chromosome
Accession NZ_CP054876
Organism Staphylococcus aureus strain Dresden-275757

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HUW54_RS04100 Protein ID WP_000052076.1
Coordinates 852189..852377 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HUW54_RS04105 Protein ID WP_001059690.1
Coordinates 852406..852666 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUW54_RS04070 847799..848701 + 903 WP_175528706.1 hypothetical protein -
HUW54_RS04075 849042..849728 + 687 WP_001566557.1 thermonuclease family protein -
HUW54_RS04080 850085..850285 + 201 WP_001059082.1 cold-shock protein -
HUW54_RS04085 850780..850998 - 219 WP_000005884.1 hypothetical protein -
HUW54_RS04090 851060..851344 - 285 WP_001004394.1 hypothetical protein -
HUW54_RS04095 851432..852001 - 570 WP_001106652.1 hypothetical protein -
HUW54_RS04100 852189..852377 - 189 WP_000052076.1 hypothetical protein Toxin
HUW54_RS04105 852406..852666 - 261 WP_001059690.1 hypothetical protein Antitoxin
HUW54_RS04110 853007..853210 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HUW54_RS04115 853207..853443 - 237 WP_000368687.1 hypothetical protein -
HUW54_RS04120 853668..854249 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
HUW54_RS04125 854322..854939 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
HUW54_RS04130 855095..855589 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
HUW54_RS04135 855988..856410 - 423 WP_000974465.1 organic hydroperoxide resistance protein -
HUW54_RS04140 856558..857274 + 717 WP_000150020.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T160566 WP_000052076.1 NZ_CP054876:c852377-852189 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T160566 NZ_CP070572:c1682509-1682324 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT160566 WP_001059690.1 NZ_CP054876:c852666-852406 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT160566 NZ_CP070572:c1682277-1681864 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References