Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 5448902..5450177 Replicon chromosome
Accession NZ_CP054874
Organism Pseudomonas protegens strain PGNL1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUT20_RS24545 Protein ID WP_041752203.1
Coordinates 5448902..5449501 (-) Length 200 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HUT20_RS24550 Protein ID WP_041752748.1
Coordinates 5449620..5450177 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT20_RS24525 (HUT20_24525) 5444068..5444982 - 915 WP_015635387.1 SGNH/GDSL hydrolase family protein -
HUT20_RS24530 (HUT20_24530) 5445217..5445645 + 429 WP_011060992.1 hypothetical protein -
HUT20_RS24535 (HUT20_24535) 5445837..5446295 - 459 WP_015635386.1 hypothetical protein -
HUT20_RS24540 (HUT20_24540) 5446506..5448686 - 2181 WP_015635385.1 catalase/peroxidase HPI -
HUT20_RS24545 (HUT20_24545) 5448902..5449501 - 600 WP_041752203.1 HD domain-containing protein Toxin
HUT20_RS24550 (HUT20_24550) 5449620..5450177 - 558 WP_041752748.1 helix-turn-helix transcriptional regulator Antitoxin
HUT20_RS24555 (HUT20_24555) 5450367..5450708 + 342 WP_041752202.1 low molecular weight protein tyrosine phosphatase family protein -
HUT20_RS24560 (HUT20_24560) 5450710..5451156 + 447 WP_230493594.1 hypothetical protein -
HUT20_RS24565 (HUT20_24565) 5451335..5452522 - 1188 WP_041752200.1 PrpF domain-containing protein -
HUT20_RS24570 (HUT20_24570) 5452934..5453521 + 588 WP_011060980.1 AidA/PixA family protein -
HUT20_RS24575 (HUT20_24575) 5453567..5454187 - 621 WP_041752198.1 LysE family translocator -
HUT20_RS24580 (HUT20_24580) 5454275..5454925 - 651 WP_041752197.1 DUF2239 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(8-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-47)


Sequences

Toxin        


Download         Length: 200 a.a.        Molecular weight: 22463.25 Da        Isoelectric Point: 5.3128

>T160564 WP_041752203.1 NZ_CP054874:c5449501-5448902 [Pseudomonas protegens]
MNSELLSGRLDFLREAEKLKDVLRSAHTSSGRQESTAEHSWRLCLMALLFEDQLGDLDLLRVLKLCIVHDLGEAIHGDIP
AVAQAAHPDKSQQERDDLQLLARALDAPAREHLLELWDEYEGAASNEARAVKALDKLETLLQHTQGQNPAGFDYRFNLGY
GRRYTDASPLFQALRQQIDIDTQRCLDAQAQAAVQHRLR

Download         Length: 600 bp

>T160564 NZ_CP070572:c97522-96209 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGTATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTATCGATGCCATTACAACTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTATTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGTGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGAATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAAAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATGATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAAAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCTCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20497.44 Da        Isoelectric Point: 7.0311

>AT160564 WP_041752748.1 NZ_CP054874:c5450177-5449620 [Pseudomonas protegens]
MSVALFTSPHLGLALRRWRLLHRVKQQHAAELFGVAQSSISRWENGRQIMEPAERARLEQLLAANLSAAADQALARLVND
SPRAVHLVCDLTHRLLACSATRAGQFGVPLSELLGQSLWGFCTEEITRKEAALDDLGWREVLEPPSLEFFSGHNDSAIVP
IAPSQCRWTRLNLSDGNAVRLVETL

Download         Length: 558 bp

>AT160564 NZ_CP070572:c97780-97523 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAAATTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References