Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 827378..827974 Replicon chromosome
Accession NZ_CP054874
Organism Pseudomonas protegens strain PGNL1

Toxin (Protein)


Gene name relE Uniprot ID A0A2C9EFT8
Locus tag HUT20_RS03855 Protein ID WP_015633982.1
Coordinates 827378..827680 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2C9EFR9
Locus tag HUT20_RS03860 Protein ID WP_015633981.1
Coordinates 827684..827974 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT20_RS03835 (HUT20_03835) 822612..823925 - 1314 WP_015633984.1 precorrin-3B synthase -
HUT20_RS03840 (HUT20_03840) 824064..825278 + 1215 WP_011059024.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
HUT20_RS03845 (HUT20_03845) 825372..826469 + 1098 WP_015633983.1 cobalt-precorrin-5B (C(1))-methyltransferase -
HUT20_RS03850 (HUT20_03850) 826466..827194 + 729 WP_011059022.1 cobalt-precorrin-6A reductase -
HUT20_RS03855 (HUT20_03855) 827378..827680 + 303 WP_015633982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUT20_RS03860 (HUT20_03860) 827684..827974 + 291 WP_015633981.1 putative addiction module antidote protein Antitoxin
HUT20_RS03865 (HUT20_03865) 828075..828473 + 399 WP_011059019.1 DUF2946 domain-containing protein -
HUT20_RS03870 (HUT20_03870) 828523..829017 + 495 WP_011059018.1 copper chaperone PCu(A)C -
HUT20_RS03875 (HUT20_03875) 829130..829483 + 354 WP_217438461.1 DUF2946 domain-containing protein -
HUT20_RS03880 (HUT20_03880) 829572..831704 + 2133 WP_015633979.1 TonB-dependent copper receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11504.34 Da        Isoelectric Point: 10.6512

>T160562 WP_015633982.1 NZ_CP054874:827378-827680 [Pseudomonas protegens]
MFVFEQTPEFSRWLLNLKDPQGKTRVLARIRAAQLGRFGDCEPVGEGVHEMRIHRGPGYRVYFSRRGKVIYLLLIGGDKA
TQKRDIQRARQLACDLKSEG

Download         Length: 303 bp

>T160562 NZ_CP070570:c17033-16746 [Proteus mirabilis]
ATGATGTATTCGGTTAAATTTAGAAAAGATGCAGAAAAGGAATGGAAAAAATTAGATAAAACCATTCAATCTCAATTTGC
CAAACAATTAATAAAACGATGTGAAAATCCACATGTAGCATCTGCAAAACTGAGAAATATGCCGAATTGCTATAAAATTA
AACTTCGTGCATCAGGTTTTAGATTGGTCTATCAAGTTATTGACGATATGTTAATTATTGCAGTTGTTGCCGTTGGCAAG
CGGGAAAAAAGTCAGGTTTATAATCTTGCCAGTGAACGCTTAAAATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10422.96 Da        Isoelectric Point: 6.2901

>AT160562 WP_015633981.1 NZ_CP054874:827684-827974 [Pseudomonas protegens]
MRTPVTRFDAAEYLKTPEDMVAYLNACFEEDTGDGVLIRAALNDIARARGMTQVARDTGLGRESLYKALGSQGNPEFATI
IKVMKALGLKINVSNA

Download         Length: 291 bp

>AT160562 NZ_CP070570:c17281-17030 [Proteus mirabilis]
ATGCCAAATACGATTTTAAGTGATACAACAGCCAGCGTCAGTGAACTCAAAAAAAACCCAATGGCGACAGTTAACGCAGG
TTTAGGCTATCCCGTAGCCATTTTAAACCGTAATCAACCTGCTTTTTACTGTGTTCCTGCTGAGTTATATGAGCAAATAC
TTGATGCGCTAGACGATAACGAACTTGCAAAGCTGGTCAAAGAACGAGAATCACAACCTCTTGTCGATATTAATTTAGCC
GAGTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9EFT8

Antitoxin

Source ID Structure
AlphaFold DB A0A2C9EFR9

References