Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3794386..3794982 Replicon chromosome
Accession NZ_CP054873
Organism Pseudomonas protegens strain PGNR2

Toxin (Protein)


Gene name relE Uniprot ID A0A2C9EFT8
Locus tag HUT21_RS17230 Protein ID WP_015633982.1
Coordinates 3794386..3794688 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2C9EFR9
Locus tag HUT21_RS17235 Protein ID WP_015633981.1
Coordinates 3794692..3794982 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT21_RS17210 (HUT21_17210) 3789620..3790933 - 1314 WP_015633984.1 precorrin-3B synthase -
HUT21_RS17215 (HUT21_17215) 3791072..3792286 + 1215 WP_011059024.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
HUT21_RS17220 (HUT21_17220) 3792380..3793477 + 1098 WP_015633983.1 cobalt-precorrin-5B (C(1))-methyltransferase -
HUT21_RS17225 (HUT21_17225) 3793474..3794202 + 729 WP_011059022.1 cobalt-precorrin-6A reductase -
HUT21_RS17230 (HUT21_17230) 3794386..3794688 + 303 WP_015633982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUT21_RS17235 (HUT21_17235) 3794692..3794982 + 291 WP_015633981.1 putative addiction module antidote protein Antitoxin
HUT21_RS17240 (HUT21_17240) 3795083..3795481 + 399 WP_011059019.1 DUF2946 domain-containing protein -
HUT21_RS17245 (HUT21_17245) 3795531..3796025 + 495 WP_011059018.1 copper chaperone PCu(A)C -
HUT21_RS17250 (HUT21_17250) 3796138..3796491 + 354 WP_217438461.1 DUF2946 domain-containing protein -
HUT21_RS17255 (HUT21_17255) 3796580..3798712 + 2133 WP_015633979.1 TonB-dependent copper receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11504.34 Da        Isoelectric Point: 10.6512

>T160561 WP_015633982.1 NZ_CP054873:3794386-3794688 [Pseudomonas protegens]
MFVFEQTPEFSRWLLNLKDPQGKTRVLARIRAAQLGRFGDCEPVGEGVHEMRIHRGPGYRVYFSRRGKVIYLLLIGGDKA
TQKRDIQRARQLACDLKSEG

Download         Length: 303 bp

>T160561 NZ_CP070569:c4041788-4041411 [Proteus mirabilis]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10422.96 Da        Isoelectric Point: 6.2901

>AT160561 WP_015633981.1 NZ_CP054873:3794692-3794982 [Pseudomonas protegens]
MRTPVTRFDAAEYLKTPEDMVAYLNACFEEDTGDGVLIRAALNDIARARGMTQVARDTGLGRESLYKALGSQGNPEFATI
IKVMKALGLKINVSNA

Download         Length: 291 bp

>AT160561 NZ_CP070569:c4042212-4041835 [Proteus mirabilis]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9EFT8

Antitoxin

Source ID Structure
AlphaFold DB A0A2C9EFR9

References