160555

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4157708..4158363 Replicon chromosome
Accession NZ_CP054871
Organism Pseudomonas protegens strain PPRAR07

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HUT23_RS18835 Protein ID WP_053159224.1
Coordinates 4157708..4157887 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUT23_RS18840 Protein ID WP_053159226.1
Coordinates 4157938..4158363 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT23_RS18805 (HUT23_18805) 4152782..4153057 + 276 WP_011061856.1 peptidylprolyl isomerase -
HUT23_RS18810 (HUT23_18810) 4153215..4154123 - 909 WP_210483806.1 sugar kinase -
HUT23_RS18815 (HUT23_18815) 4154582..4155799 - 1218 WP_210458474.1 amino acid deaminase -
HUT23_RS18820 (HUT23_18820) 4155847..4156611 - 765 WP_011061859.1 IclR family transcriptional regulator -
HUT23_RS18825 (HUT23_18825) 4156762..4157151 - 390 WP_011061860.1 RidA family protein -
HUT23_RS18830 (HUT23_18830) 4157470..4157619 + 150 WP_155494419.1 hypothetical protein -
HUT23_RS18835 (HUT23_18835) 4157708..4157887 + 180 WP_053159224.1 type II toxin-antitoxin system HicA family toxin Toxin
HUT23_RS18840 (HUT23_18840) 4157938..4158363 + 426 WP_053159226.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUT23_RS18845 (HUT23_18845) 4158451..4158996 - 546 WP_210483803.1 hypothetical protein -
HUT23_RS18850 (HUT23_18850) 4159043..4159222 - 180 WP_123725200.1 hypothetical protein -
HUT23_RS18855 (HUT23_18855) 4159358..4160791 - 1434 WP_019095389.1 RtcB family protein -
HUT23_RS18860 (HUT23_18860) 4161299..4162315 - 1017 WP_210483800.1 fimbrial protein -
HUT23_RS18865 (HUT23_18865) 4162622..4163194 + 573 WP_053152414.1 type 1 glutamine amidotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6632.67 Da        Isoelectric Point: 11.1475

>T160555 WP_053159224.1 NZ_CP054871:4157708-4157887 [Pseudomonas protegens]
MKFSEFRRWLKAQGVVFEAGKGSHFKVTAPNGNKTTFADHGSKEMPEPTRKAIIRQLGL

Download         Length: 180 bp

>T160555 NZ_CP070569:c114637-114254 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGAGCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15743.06 Da        Isoelectric Point: 4.7790

>AT160555 WP_053159226.1 NZ_CP054871:4157938-4158363 [Pseudomonas protegens]
MYDYAIRFEQDRAPGVAVFCRDLPELNSFGDDPEHAINQAIDALETTLSLYVDQRRAIPPASEPLPGEQVIHLPMVTVAK
IALWNTMMERDMRKADLCRLLGIHQAQGDRLVDFLHSSKMEQLENALAALGKRLAVSVEAA

Download         Length: 426 bp

>AT160555 NZ_CP070569:c114855-114634 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATACTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References