Detailed information of TA system TA160552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2517747..2518369
• Replicon: chromosome
• Accession: NZ_CP054871
• Organism: Pseudomonas protegens strain PPRAR07

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HUT23_RS11580
• Protein ID: WP_210482334.1
• Coordinates: 2518187..2518369 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HUT23_RS11575
• Protein ID: WP_077933771.1
• Coordinates: 2517747..2518148 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUT23_RS11550 (HUT23_11565)	2514525..2514959	-	435	WP_015634968.1	hypothetical protein	-
HUT23_RS11555 (HUT23_11570)	2514992..2515360	-	369	WP_077933769.1	antibiotic biosynthesis monooxygenase family protein	-
HUT23_RS11560 (HUT23_11575)	2515494..2515928	+	435	WP_019094724.1	MarR family winged helix-turn-helix transcriptional regulator	-
HUT23_RS11565 (HUT23_11580)	2516173..2516880	-	708	WP_077933770.1	DUF1266 domain-containing protein	-
HUT23_RS11570 (HUT23_11585)	2516952..2517224	-	273	WP_227454132.1	DUF5339 family protein	-
HUT23_RS11575 (HUT23_11590)	2517747..2518148	-	402	WP_077933771.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HUT23_RS11580 (HUT23_11595)	2518187..2518369	-	183	WP_210482334.1	type II toxin-antitoxin system HicA family toxin	Toxin
HUT23_RS11585 (HUT23_11600)	2518512..2519210	-	699	WP_041117166.1	arsenical resistance protein ArsH	-
HUT23_RS11590 (HUT23_11605)	2519220..2519690	-	471	WP_152686094.1	arsenate reductase ArsC	-
HUT23_RS11595 (HUT23_11610)	2519721..2521004	-	1284	WP_019094718.1	arsenic transporter	-
HUT23_RS11600 (HUT23_11615)	2521025..2521372	-	348	WP_169894003.1	metalloregulator ArsR/SmtB family transcription factor	-
HUT23_RS11605 (HUT23_11620)	2521602..2522156	+	555	WP_210482333.1	hypothetical protein	-
HUT23_RS11610 (HUT23_11625)	2522363..2522794	-	432	WP_011060488.1	carboxymuconolactone decarboxylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2510532..2531067	20535

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6836.02 Da
• Isoelectric Point: 11.5631

>T160552 WP_210482334.1 NZ_CP054871:c2518369-2518187 [Pseudomonas protegens]
VQSRLLFKELEAAGWVLERVTGSHHLFQHPYRPNTVPVPHTKKDLPRGTVRAIRKLAGLL

Nucleotide

• Length: 183 bp

>T160552 NZ_CP070568:4033335-4033703 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14514.49 Da
• Isoelectric Point: 5.1222

>AT160552 WP_077933771.1 NZ_CP054871:c2518148-2517747 [Pseudomonas protegens]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAVEIAHLMLEELARAGQAIPLPSATQTHRAHPDYQGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVRAHNIKSRSSFLADAALEKLGR

Nucleotide

• Length: 402 bp

>AT160552 NZ_CP070568:4033117-4033338 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA