Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 774345..774941 Replicon chromosome
Accession NZ_CP054871
Organism Pseudomonas protegens strain PPRAR07

Toxin (Protein)


Gene name relE Uniprot ID A0A2C9EFT8
Locus tag HUT23_RS03425 Protein ID WP_015633982.1
Coordinates 774639..774941 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4KIY9
Locus tag HUT23_RS03420 Protein ID WP_011059020.1
Coordinates 774345..774635 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT23_RS03400 (HUT23_03405) 770615..772747 - 2133 WP_210457652.1 TonB-dependent copper receptor -
HUT23_RS03405 (HUT23_03410) 772836..773189 - 354 WP_202602847.1 DUF2946 domain-containing protein -
HUT23_RS03410 (HUT23_03415) 773302..773796 - 495 WP_011059018.1 copper chaperone PCu(A)C -
HUT23_RS03415 (HUT23_03420) 773846..774244 - 399 WP_210457651.1 DUF2946 domain-containing protein -
HUT23_RS03420 (HUT23_03425) 774345..774635 - 291 WP_011059020.1 putative addiction module antidote protein Antitoxin
HUT23_RS03425 (HUT23_03430) 774639..774941 - 303 WP_015633982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUT23_RS03430 (HUT23_03435) 775125..775853 - 729 WP_011059022.1 cobalt-precorrin-6A reductase -
HUT23_RS03435 (HUT23_03440) 775850..776947 - 1098 WP_210457650.1 cobalt-precorrin-5B (C(1))-methyltransferase -
HUT23_RS03440 (HUT23_03445) 777041..778255 - 1215 WP_011059024.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
HUT23_RS03445 (HUT23_03450) 778394..779707 + 1314 WP_210482715.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11504.34 Da        Isoelectric Point: 10.6512

>T160551 WP_015633982.1 NZ_CP054871:c774941-774639 [Pseudomonas protegens]
MFVFEQTPEFSRWLLNLKDPQGKTRVLARIRAAQLGRFGDCEPVGEGVHEMRIHRGPGYRVYFSRRGKVIYLLLIGGDKA
TQKRDIQRARQLACDLKSEG

Download         Length: 303 bp

>T160551 NZ_CP070568:c3632780-3632397 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10423.94 Da        Isoelectric Point: 5.0939

>AT160551 WP_011059020.1 NZ_CP054871:c774635-774345 [Pseudomonas protegens]
MRTPVTRFDAAEYLKTPEDMVAYLDACFEEDTGDGVLIRAALNDIARARGMTQVARDTGLGRESLYKALGSQGNPEFATI
IKVMKALGLKINVSNA

Download         Length: 291 bp

>AT160551 NZ_CP070568:c3633022-3632780 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9EFT8

Antitoxin

Source ID Structure
AlphaFold DB Q4KIY9

References