Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1866615..1867237 Replicon chromosome
Accession NZ_CP054868
Organism Pseudomonas chlororaphis strain PCLAR04

Toxin (Protein)


Gene name hicA Uniprot ID A0A2N8AR08
Locus tag HUT26_RS08320 Protein ID WP_007929414.1
Coordinates 1866615..1866797 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8AQX2
Locus tag HUT26_RS08325 Protein ID WP_063429381.1
Coordinates 1866830..1867237 (+) Length 136 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT26_RS08275 (HUT26_08280) 1861783..1862382 + 600 WP_210478810.1 DUF1566 domain-containing protein -
HUT26_RS08280 (HUT26_08285) 1862431..1863153 + 723 WP_210478812.1 hypothetical protein -
HUT26_RS08285 (HUT26_08290) 1863150..1863905 + 756 WP_210478814.1 hypothetical protein -
HUT26_RS08290 (HUT26_08295) 1863902..1864105 + 204 WP_210478815.1 hypothetical protein -
HUT26_RS08295 (HUT26_08300) 1864102..1864839 + 738 WP_210478817.1 metallophosphoesterase -
HUT26_RS08300 (HUT26_08305) 1864836..1865117 + 282 WP_210478819.1 hypothetical protein -
HUT26_RS08305 (HUT26_08310) 1865114..1865281 + 168 WP_210478820.1 hypothetical protein -
HUT26_RS08310 (HUT26_08315) 1865274..1865768 + 495 WP_210478822.1 hypothetical protein -
HUT26_RS08315 (HUT26_08320) 1865807..1866034 + 228 WP_210478823.1 hypothetical protein -
HUT26_RS08320 (HUT26_08325) 1866615..1866797 + 183 WP_007929414.1 type II toxin-antitoxin system HicA family toxin Toxin
HUT26_RS08325 (HUT26_08330) 1866830..1867237 + 408 WP_063429381.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUT26_RS08330 (HUT26_08335) 1867483..1867950 + 468 WP_063428841.1 GAF domain-containing protein -
HUT26_RS08335 (HUT26_08340) 1868080..1868994 + 915 WP_063428839.1 SGNH/GDSL hydrolase family protein -
HUT26_RS08340 (HUT26_08345) 1869028..1870806 - 1779 WP_063428837.1 GGDEF and EAL domain-containing protein -
HUT26_RS08345 (HUT26_08350) 1871042..1871935 - 894 WP_173678573.1 LysR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1826378..1871935 45557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6850.15 Da        Isoelectric Point: 11.6709

>T160547 WP_007929414.1 NZ_CP054868:1866615-1866797 [Pseudomonas chlororaphis]
VNSRYLIGQIVADGWYLVRVRGSHHHFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

>T160547 NZ_CP070568:c2260626-2260309 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14604.60 Da        Isoelectric Point: 4.3638

>AT160547 WP_063429381.1 NZ_CP054868:1866830-1867237 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp

>AT160547 NZ_CP070568:c2260316-2260029 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2N8AR08


Antitoxin

Source ID Structure
AlphaFold DB A0A2N8AQX2

References