Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 933684..934269 Replicon chromosome
Accession NZ_CP054868
Organism Pseudomonas chlororaphis strain PCLAR04

Toxin (Protein)


Gene name PumA Uniprot ID A0A3G7C0N8
Locus tag HUT26_RS03905 Protein ID WP_025804099.1
Coordinates 933684..933977 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag HUT26_RS03910 Protein ID WP_025804100.1
Coordinates 933979..934269 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT26_RS03885 (HUT26_03890) 929141..929539 - 399 WP_025804095.1 carboxymuconolactone decarboxylase family protein -
HUT26_RS03890 (HUT26_03895) 929740..930984 - 1245 WP_025804096.1 M20/M25/M40 family metallo-hydrolase -
HUT26_RS03895 (HUT26_03900) 931078..931686 - 609 Protein_779 GGDEF domain-containing protein -
HUT26_RS03900 (HUT26_03905) 932054..933448 + 1395 WP_124302682.1 VOC family protein -
HUT26_RS03905 (HUT26_03910) 933684..933977 + 294 WP_025804099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUT26_RS03910 (HUT26_03915) 933979..934269 + 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
HUT26_RS03915 (HUT26_03920) 934683..935270 - 588 WP_025804101.1 hypothetical protein -
HUT26_RS03920 (HUT26_03925) 935398..936474 - 1077 WP_025804102.1 lipocalin-like domain-containing protein -
HUT26_RS03925 (HUT26_03930) 936464..938908 - 2445 WP_210478631.1 FtsX-like permease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10837.49 Da        Isoelectric Point: 10.7289

>T160545 WP_025804099.1 NZ_CP054868:933684-933977 [Pseudomonas chlororaphis]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNRGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

>T160545 NZ_CP070568:367174-367276 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT160545 WP_025804100.1 NZ_CP054868:933979-934269 [Pseudomonas chlororaphis]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT160545 NZ_CP070568:c367283-367138 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7C0N8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References