Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 209345..209861 Replicon chromosome
Accession NZ_CP054867
Organism Pseudomonas chlororaphis strain PCLRT02

Toxin (Protein)


Gene name stbE Uniprot ID A0A8A9Z863
Locus tag HUT27_RS00880 Protein ID WP_028681510.1
Coordinates 209580..209861 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A554PKE4
Locus tag HUT27_RS00875 Protein ID WP_009046356.1
Coordinates 209345..209590 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT27_RS00850 (HUT27_00850) 205113..206108 + 996 WP_041985268.1 aspartyl beta-hydroxylase -
HUT27_RS00855 (HUT27_00855) 206074..206832 - 759 WP_009046352.1 slipin family protein -
HUT27_RS00860 (HUT27_00860) 206834..208219 - 1386 WP_009046353.1 nodulation protein NfeD -
HUT27_RS00865 (HUT27_00865) 208443..208904 + 462 WP_016705004.1 YbaK/EbsC family protein -
HUT27_RS00870 (HUT27_00870) 209035..209280 + 246 WP_009046355.1 DUF2789 domain-containing protein -
HUT27_RS00875 (HUT27_00875) 209345..209590 + 246 WP_009046356.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUT27_RS00880 (HUT27_00880) 209580..209861 + 282 WP_028681510.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUT27_RS00885 (HUT27_00885) 209994..210422 + 429 WP_009046358.1 MarR family transcriptional regulator -
HUT27_RS00890 (HUT27_00890) 210419..212503 + 2085 WP_150084957.1 FUSC family protein -
HUT27_RS00895 (HUT27_00895) 212500..212709 + 210 WP_007932080.1 DUF1656 domain-containing protein -
HUT27_RS00900 (HUT27_00900) 212706..213602 + 897 WP_038630331.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10907.82 Da        Isoelectric Point: 10.6258

>T160539 WP_028681510.1 NZ_CP054867:209580-209861 [Pseudomonas chlororaphis]
MTYKLQFLPSARKEWDKLGHTLREQFKRKLAERLEMPRVPADALHGMADCYKIKLKASGYRLVYQVIEDQVVVSVVAVGK
RERSAVYERARKR

Download         Length: 282 bp

>T160539 NZ_CP070564:c4797170-4796823 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8814.14 Da        Isoelectric Point: 4.7164

>AT160539 WP_009046356.1 NZ_CP054867:209345-209590 [Pseudomonas chlororaphis]
MQSVLADKAVSVSELKKNPSAVLNGAQGGAVAVLNHNRVMGYMVPADVFEAMMERLDDLELAEIVRARRHETPVPVNLDD
L

Download         Length: 246 bp

>AT160539 NZ_CP070564:c4796823-4796524 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A9Z863

Antitoxin

Source ID Structure
AlphaFold DB A0A554PKE4

References