Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6200476..6201065 Replicon chromosome
Accession NZ_CP054865
Organism Pseudomonas chlororaphis strain PCLSL01

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HUT29_RS27580 Protein ID WP_016702674.1
Coordinates 6200766..6201065 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HUT29_RS27575 Protein ID WP_053281098.1
Coordinates 6200476..6200769 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT29_RS27545 (HUT29_27560) 6195556..6196089 + 534 WP_025807757.1 2,4'-dihydroxyacetophenone dioxygenase family protein -
HUT29_RS27550 (HUT29_27565) 6196264..6197058 + 795 WP_025807760.1 SDR family NAD(P)-dependent oxidoreductase -
HUT29_RS27555 (HUT29_27570) 6197237..6197917 + 681 WP_025807762.1 isochorismatase family protein -
HUT29_RS27560 (HUT29_27575) 6198103..6198507 + 405 WP_063433159.1 DoxX family protein -
HUT29_RS27565 (HUT29_27580) 6198714..6199106 + 393 WP_063433160.1 DUF3077 domain-containing protein -
HUT29_RS27570 (HUT29_27585) 6199307..6200470 + 1164 WP_063433161.1 GGDEF domain-containing protein -
HUT29_RS27575 (HUT29_27590) 6200476..6200769 - 294 WP_053281098.1 putative addiction module antidote protein Antitoxin
HUT29_RS27580 (HUT29_27595) 6200766..6201065 - 300 WP_016702674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUT29_RS27585 (HUT29_27600) 6201239..6201688 + 450 WP_063433162.1 DUF3828 domain-containing protein -
HUT29_RS27590 (HUT29_27605) 6201713..6202723 - 1011 WP_196762739.1 NAD(P)-dependent alcohol dehydrogenase -
HUT29_RS27595 (HUT29_27610) 6202779..6203078 - 300 WP_007924100.1 helix-turn-helix transcriptional regulator -
HUT29_RS27600 (HUT29_27615) 6203145..6204233 - 1089 WP_025807778.1 copper-containing nitrite reductase -
HUT29_RS27605 (HUT29_27620) 6204460..6204702 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
HUT29_RS27610 (HUT29_27625) 6204699..6205586 + 888 WP_053281103.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11221.93 Da        Isoelectric Point: 10.6086

>T160538 WP_016702674.1 NZ_CP054865:c6201065-6200766 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQLGSQLVILLCGGDKS
RQSRDIELAKQLARRWSRS

Download         Length: 300 bp

>T160538 NZ_CP070564:c4410983-4410498 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10584.16 Da        Isoelectric Point: 6.4627

>AT160538 WP_053281098.1 NZ_CP054865:c6200769-6200476 [Pseudomonas chlororaphis]
MNEPLFDYDPATSLRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHVRP

Download         Length: 294 bp

>AT160538 NZ_CP070564:c4411273-4410980 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References