Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2368771..2369356 Replicon chromosome
Accession NZ_CP054865
Organism Pseudomonas chlororaphis strain PCLSL01

Toxin (Protein)


Gene name PumA Uniprot ID A0A3G7C0N8
Locus tag HUT29_RS10690 Protein ID WP_025804099.1
Coordinates 2369063..2369356 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag HUT29_RS10685 Protein ID WP_025804100.1
Coordinates 2368771..2369061 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUT29_RS10670 (HUT29_10670) 2364060..2366576 + 2517 WP_246882996.1 FtsX-like permease family protein -
HUT29_RS10675 (HUT29_10675) 2366566..2367642 + 1077 WP_210472484.1 lipocalin-like domain-containing protein -
HUT29_RS10680 (HUT29_10680) 2367770..2368357 + 588 WP_210472486.1 hypothetical protein -
HUT29_RS10685 (HUT29_10685) 2368771..2369061 - 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
HUT29_RS10690 (HUT29_10690) 2369063..2369356 - 294 WP_025804099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUT29_RS10695 (HUT29_10695) 2369592..2370986 - 1395 WP_210472488.1 VOC family protein -
HUT29_RS10700 (HUT29_10700) 2371249..2372373 + 1125 WP_102677245.1 diguanylate cyclase -
HUT29_RS10705 (HUT29_10705) 2372467..2373711 + 1245 WP_025804096.1 M20/M25/M40 family metallo-hydrolase -
HUT29_RS10710 (HUT29_10710) 2373912..2374310 + 399 WP_025804095.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10837.49 Da        Isoelectric Point: 10.7289

>T160537 WP_025804099.1 NZ_CP054865:c2369356-2369063 [Pseudomonas chlororaphis]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNRGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

>T160537 NZ_CP070564:c4277920-4277510 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT160537 WP_025804100.1 NZ_CP054865:c2369061-2368771 [Pseudomonas chlororaphis]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT160537 NZ_CP070564:c4278167-4277901 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7C0N8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References