Detailed information of TA system TA160536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2355172..2355791
• Replicon: chromosome
• Accession: NZ_CP054865
• Organism: Pseudomonas chlororaphis strain PCLSL01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HUT29_RS10620
• Protein ID: WP_053278351.1
• Coordinates: 2355609..2355791 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HUT29_RS10615
• Protein ID: WP_124373023.1
• Coordinates: 2355172..2355573 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUT29_RS10600 (HUT29_10600)	2351251..2353140	+	1890	WP_210472480.1	PAS domain S-box protein	-
HUT29_RS10605 (HUT29_10605)	2353137..2353772	+	636	WP_023968669.1	response regulator transcription factor	-
HUT29_RS10610 (HUT29_10610)	2353866..2354630	+	765	WP_210472481.1	hypothetical protein	-
HUT29_RS10615 (HUT29_10615)	2355172..2355573	-	402	WP_124373023.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HUT29_RS10620 (HUT29_10620)	2355609..2355791	-	183	WP_053278351.1	type II toxin-antitoxin system HicA family toxin	Toxin
HUT29_RS10625 (HUT29_10625)	2356042..2356599	-	558	WP_241190452.1	zinc ribbon domain-containing protein	-
HUT29_RS10630 (HUT29_10630)	2357162..2357443	-	282	WP_124373024.1	hypothetical protein	-
HUT29_RS10635 (HUT29_10635)	2358028..2358612	+	585	WP_124373025.1	hypothetical protein	-
HUT29_RS10640 (HUT29_10640)	2358699..2359796	+	1098	WP_124373026.1	hypothetical protein	-
HUT29_RS10645 (HUT29_10645)	2360021..2360569	-	549	WP_124373027.1	YniB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6799.98 Da
• Isoelectric Point: 10.9678

>T160536 WP_053278351.1 NZ_CP054865:c2355791-2355609 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLL

Nucleotide

• Length: 183 bp

>T160536 NZ_CP070564:c3158151-3158049 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14607.59 Da
• Isoelectric Point: 4.6017

>AT160536 WP_124373023.1 NZ_CP054865:c2355573-2355172 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIVHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Nucleotide

• Length: 402 bp

>AT160536 NZ_CP070564:3158042-3158187 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT