Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 173029..173714 Replicon plasmid unnamed1
Accession NZ_CP054862
Organism Martelella sp. NC20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HQ843_RS27440 Protein ID WP_180902599.1
Coordinates 173292..173714 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HQ843_RS27435 Protein ID WP_180902600.1
Coordinates 173029..173295 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ843_RS27410 168137..168967 + 831 WP_180902604.1 DUF3883 domain-containing protein -
HQ843_RS27415 169079..169828 - 750 WP_180902603.1 DUF1275 domain-containing protein -
HQ843_RS27420 170016..170702 - 687 WP_180902602.1 SMC-Scp complex subunit ScpB -
HQ843_RS27425 170705..171658 - 954 WP_180903546.1 DUF1403 family protein -
HQ843_RS27430 171805..172884 + 1080 WP_180902601.1 tyrosine-type recombinase/integrase -
HQ843_RS27435 173029..173295 + 267 WP_180902600.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HQ843_RS27440 173292..173714 + 423 WP_180902599.1 type II toxin-antitoxin system VapC family toxin Toxin
HQ843_RS27445 174048..175142 + 1095 WP_180902598.1 Fic family protein -
HQ843_RS27450 175343..176659 - 1317 WP_180902597.1 replication initiation protein RepC -
HQ843_RS27455 176865..177869 - 1005 WP_180902596.1 plasmid partitioning protein RepB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..259514 259514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-72)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15670.00 Da        Isoelectric Point: 4.6869

>T160532 WP_180902599.1 NZ_CP054862:173292-173714 [Martelella sp. NC20]
VNLLLDTNVLSEVTKPRPEGRVLLWLDGLDEDRCFISVVSLAEIRRGVALMDDGRKRDALAEWLAHDLPQRFEHRVFAVD
ERVALAWGDLMGEAKRRGRGMSSMDGLIAATAMAYDLVLATRNVKDFEGFGMDLIDPWAA

Download         Length: 423 bp

>T160532 NZ_CP070564:370999-371283 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9837.15 Da        Isoelectric Point: 8.7353

>AT160532 WP_180902600.1 NZ_CP054862:173029-173295 [Martelella sp. NC20]
MQPVSHDEKNWTVAKAKAKLSEVIERAQSTPQTITRNGKPSVVVVSAEEWQRKVARKGTLAEFLLASPLRGAELDLNRQD
DEPRDLSL

Download         Length: 267 bp

>AT160532 NZ_CP070564:370767-371009 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References