Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 4968625..4969295 Replicon chromosome
Accession NZ_CP054858
Organism Martelella sp. NC18

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HQ775_RS23760 Protein ID WP_180899192.1
Coordinates 4968625..4969026 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HQ775_RS23765 Protein ID WP_180899193.1
Coordinates 4969023..4969295 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ775_RS23735 4963789..4964292 + 504 WP_180899187.1 disulfide bond formation protein B -
HQ775_RS23740 4964362..4965354 - 993 WP_180899188.1 KpsF/GutQ family sugar-phosphate isomerase -
HQ775_RS23745 4965746..4966633 - 888 WP_180899189.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
HQ775_RS23750 4966788..4968242 - 1455 WP_180899190.1 glutamate synthase subunit beta -
HQ775_RS23755 4968256..4968579 - 324 WP_180899191.1 heavy metal-binding domain-containing protein -
HQ775_RS23760 4968625..4969026 - 402 WP_180899192.1 type II toxin-antitoxin system VapC family toxin Toxin
HQ775_RS23765 4969023..4969295 - 273 WP_180899193.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HQ775_RS23770 4969354..4974078 - 4725 WP_180899194.1 glutamate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15139.50 Da        Isoelectric Point: 5.8050

>T160527 WP_180899192.1 NZ_CP054858:c4969026-4968625 [Martelella sp. NC18]
VSYLFDTNAISDMIRRPAGKIAQRLVGLEKRDLKTSLIVAAELRYGVVKRGSKELSELMERVLSQFEILPWEPPADIRYA
ELRNHLRQIGQPIGDMDMLIAAHALAIDAVVVTANEREFERVPGLKVENWERD

Download         Length: 402 bp

>T160527 NZ_CP070553:1259943-1260425 [Morganella morganii]
TTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCATTGGCTGAAAACCCGCGCATTGCA
AAATCAGCAATCCGGAGCCTCACGGACATTTGTCGTCTGCCACCATAACCGGATAATGGCCTATTATGCATTATCGACAG
GTGTGATTACCTGTTCACAGGCGGCGGGTCGTTTCAGGCGTAATATGCCCCCGGAAATTCCGGTTATCCTGCCGGGACGT
CTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGATGCCGCACTGCGGGTCTTGCAGGC
GGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCAGACGTTTTTATGAGCATACCGGTT
TTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAGCTGGCAACCGGTATCTATTCTGAA
TAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10484.09 Da        Isoelectric Point: 4.6768

>AT160527 WP_180899193.1 NZ_CP054858:c4969295-4969023 [Martelella sp. NC18]
MSNRITKEKKSRIFMNGRSRAVRIPSEFELEGDEVIIRQEESGLITIEPVKKKMTPRELIEWLRSKAPLGEELPEIEDLP
PREVDLDLPE

Download         Length: 273 bp

>AT160527 NZ_CP070553:1259608-1259916 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References