Detailed information of TA system TA160526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 4433222..4433832
• Replicon: chromosome
• Accession: NZ_CP054858
• Organism: Martelella sp. NC18

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: HQ775_RS21145
• Protein ID: WP_180898519.1
• Coordinates: 4433539..4433832 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HQ775_RS21140
• Protein ID: WP_180898518.1
• Coordinates: 4433222..4433542 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ775_RS21125	4430002..4431423	+	1422	WP_180898515.1	circularly permuted type 2 ATP-grasp protein	-
HQ775_RS21130	4431426..4432364	+	939	WP_180898516.1	alpha-E domain-containing protein	-
HQ775_RS21135	4432394..4433212	+	819	WP_180898517.1	transglutaminase family protein	-
HQ775_RS21140	4433222..4433542	-	321	WP_180898518.1	putative addiction module antidote protein	Antitoxin
HQ775_RS21145	4433539..4433832	-	294	WP_180898519.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HQ775_RS21150	4433957..4435459	-	1503	WP_180898520.1	IMP dehydrogenase	-
HQ775_RS21155	4435643..4436632	-	990	WP_180898521.1	MBL fold metallo-hydrolase	-
HQ775_RS21160	4436823..4438232	+	1410	WP_180898523.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-94)

Antitoxin

• Uncharacterized protein HI1420 (10-100)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10913.53 Da
• Isoelectric Point: 10.2993

>T160526 WP_180898519.1 NZ_CP054858:c4433832-4433539 [Martelella sp. NC18]
MSEVLQTGAFSAWLSDLRDREARARIIARIRRIEQGNLGDVKSLGNGLGEVRIHHGPGYRLYFCRRGEAIVILLCGGDKS
AQERDIQRAREFLKGMS

Nucleotide

• Length: 294 bp

>T160526 NZ_CP070553:107800-108003 [Morganella morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGATGAGCTGGAAGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11187.65 Da
• Isoelectric Point: 4.5341

>AT160526 WP_180898518.1 NZ_CP054858:c4433542-4433222 [Martelella sp. NC18]
MTEIGKHAELTPFDAAGYLETPEDIAFYLEAVLEDGDPALIAAALGDVARSKGMSAVSRRAGVTREALYKALSENGDPKL
STLIGVLKALGLQLAVRPENHHDDAA

Nucleotide

• Length: 321 bp

>AT160526 NZ_CP070553:107377-107736 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTCGTCCACTAA