Detailed information of TA system TA160525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/couple_hipB(antitoxin)
• Location: 2527733..2528335
• Replicon: chromosome
• Accession: NZ_CP054858
• Organism: Martelella sp. NC18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HQ775_RS12010
• Protein ID: WP_180901741.1
• Coordinates: 2528090..2528335 (-)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HQ775_RS12005
• Protein ID: WP_180901740.1
• Coordinates: 2527733..2528083 (-)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ775_RS11970	2523284..2523526	-	243	WP_180901735.1	hypothetical protein	-
HQ775_RS11975	2523529..2524074	-	546	WP_180901736.1	hypothetical protein	-
HQ775_RS11980	2524364..2525152	-	789	WP_180901737.1	XRE family transcriptional regulator	-
HQ775_RS11985	2525238..2525453	+	216	WP_180902129.1	helix-turn-helix domain-containing protein	-
HQ775_RS11990	2525626..2526105	+	480	WP_180901738.1	hypothetical protein	-
HQ775_RS11995	2526107..2526685	+	579	WP_180901739.1	hypothetical protein	-
HQ775_RS12000	2526960..2527700	+	741	WP_180902130.1	hypothetical protein	-
HQ775_RS12005	2527733..2528083	-	351	WP_180901740.1	helix-turn-helix transcriptional regulator	Antitoxin
HQ775_RS12010	2528090..2528335	-	246	WP_180901741.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
HQ775_RS12015	2528425..2529255	+	831	WP_180901742.1	DUF1376 domain-containing protein	-
HQ775_RS12020	2529284..2529685	+	402	WP_180901743.1	hypothetical protein	-
HQ775_RS12025	2529678..2530409	+	732	WP_180901744.1	hypothetical protein	-
HQ775_RS12030	2530406..2531041	+	636	WP_180901745.1	antitermination protein NusG	-
HQ775_RS12035	2531194..2532417	-	1224	WP_180901746.1	HPP family protein	-
HQ775_RS12040	2532591..2533331	+	741	WP_180901747.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2522233..2559403	37170

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (62-115)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9152.84 Da
• Isoelectric Point: 10.8582

>T160525 WP_180901741.1 NZ_CP054858:c2528335-2528090 [Martelella sp. NC18]
MKTIRYTKVAMKSIQRMQPKRRNAIIAKIEAFASGETVDLKKLQGSPYFRIRVGSDRIILDDQGLVVMIIDAGPRGGIYK
E

Nucleotide

• Length: 246 bp

>T160525 NZ_CP070550:c39925-39509 [Morganella morganii]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 12695.34 Da
• Isoelectric Point: 4.3047

>AT160525 WP_180901740.1 NZ_CP054858:c2528083-2527733 [Martelella sp. NC18]
MGEVQKITIEGNNYVLLREADYDDMLDSLHARAVMAGVDAGEETYPHELIVALSDETQSRLRVWRKYRGLTMKALAEKAG
ISQPYLSDIENGKADGSISAIKALAAALDVDIDDLV

Nucleotide

• Length: 351 bp

>AT160525 NZ_CP070550:c40152-39922 [Morganella morganii]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA