Detailed information of TA system TA160524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4479310..4480883
• Replicon: chromosome
• Accession: NZ_CP054855
• Organism: Aeromonas veronii strain 1708-29120

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HUI97_RS20525
• Protein ID: WP_206900828.1
• Coordinates: 4479310..4480629 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3Q8DTG9
• Locus tag: HUI97_RS20530
• Protein ID: WP_042047685.1
• Coordinates: 4480629..4480883 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUI97_RS20510	4475226..4475990	+	765	WP_206900826.1	ATP-binding cassette domain-containing protein	-
HUI97_RS20515	4476024..4476908	+	885	WP_206902071.1	ABC transporter substrate-binding protein	-
HUI97_RS20520	4476905..4478887	+	1983	WP_206900827.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
HUI97_RS20525	4479310..4480629	-	1320	WP_206900828.1	HipA domain-containing protein	Toxin
HUI97_RS20530	4480629..4480883	-	255	WP_042047685.1	helix-turn-helix domain-containing protein	Antitoxin
HUI97_RS20535	4481422..4482045	+	624	WP_075112291.1	recombinase family protein	-
HUI97_RS20540	4482812..4485277	+	2466	WP_096117951.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49467.63 Da
• Isoelectric Point: 7.0146

>T160524 WP_206900828.1 NZ_CP054855:c4480629-4479310 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHVSWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNMEVRSRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELKQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGLWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANAV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T160524 NZ_CP070550:c33151-32837 [Morganella morganii]
ATGCAATTCACTGTATATAGTAATACAGGGAAAAGTGCCGTTTATCCCCTGCTGATTGATGTAACAAGCGATATTATCGG
CCAGTTAAACCGGAGGATTGTTATCCCCCTGTTACCTGTTGGAATGTACCCTAATGGTATGCGACCGGAGCGCCTGACTC
CGCTTATCAGGCTGGTTGATGATAATGAGTATGTAGTCATGACTCATGAAATGGCGAGTATTCCTGCTCGTTCTTTGGGG
GCTGCGTTCTGTGATGCTTCTTCTTATCGTAAGCAGATCAAGGATGCTATTGATTTTCTTCTCGATGGTATTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT160524 WP_042047685.1 NZ_CP054855:c4480883-4480629 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT160524 NZ_CP070550:c33390-33154 [Morganella morganii]
ATGGCTGTAACACAACGACCAATGCAAACCGTAACCATGACGGTAAAACGAACCTTGCTCACCCGTGCGCGTGAGGCTGG
AATTAATTTGAGCGCCACCCTGACCGCTGCCCTCGATGCTGAATTACGTCAGTACGAAGCCAAGAGGTGGCAAGAGGAAA
ACAGCGAAGCACTGGAAGCCCTCAATCGCTTCCACGACGAACACGGCTGTTTCAGTGATGAATACAGGACATTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Q8DTG9