160518

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1107340..1107954 Replicon chromosome
Accession NZ_CP054845
Organism Pseudomonas aeruginosa strain SE5429

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag HUS13_RS05290 Protein ID WP_071534354.1
Coordinates 1107340..1107522 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag HUS13_RS05295 Protein ID WP_012077229.1
Coordinates 1107550..1107954 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS13_RS05265 1102981..1103376 + 396 WP_003094374.1 hypothetical protein -
HUS13_RS05270 1103369..1104745 + 1377 WP_003094371.1 class II fumarate hydratase -
HUS13_RS05275 1104773..1105222 + 450 WP_003094369.1 hypothetical protein -
HUS13_RS05280 1105235..1105846 + 612 WP_003094367.1 superoxide dismutase -
HUS13_RS05285 1105865..1106797 + 933 WP_019485801.1 ZIP family metal transporter -
HUS13_RS05290 1107340..1107522 + 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
HUS13_RS05295 1107550..1107954 + 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUS13_RS05300 1107997..1108968 - 972 WP_202096839.1 hypothetical protein -
HUS13_RS05305 1108953..1109651 - 699 WP_033896049.1 hypothetical protein -
HUS13_RS05310 1109651..1110190 - 540 WP_012074127.1 hypothetical protein -
HUS13_RS05315 1110187..1111107 - 921 WP_012074128.1 hypothetical protein -
HUS13_RS05320 1111104..1111814 - 711 WP_012074129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1107340..1144833 37493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T160518 WP_071534354.1 NZ_CP054845:1107340-1107522 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T160518 NZ_CP070549:c3171354-3171079 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT160518 WP_012077229.1 NZ_CP054845:1107550-1107954 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT160518 NZ_CP070549:c3171082-3170723 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References