Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147323..147828 Replicon chromosome
Accession NZ_CP054845
Organism Pseudomonas aeruginosa strain SE5429

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUS13_RS00655 Protein ID WP_003083773.1
Coordinates 147323..147604 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUS13_RS00660 Protein ID WP_003083775.1
Coordinates 147601..147828 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS13_RS00630 142574..143923 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
HUS13_RS00635 143972..144658 + 687 WP_003083762.1 FadR family transcriptional regulator -
HUS13_RS00640 144759..145493 + 735 WP_003083764.1 GntR family transcriptional regulator -
HUS13_RS00645 145697..146083 + 387 WP_003083767.1 aegerolysin family protein -
HUS13_RS00650 146115..147023 - 909 WP_003083769.1 LysR family transcriptional regulator -
HUS13_RS00655 147323..147604 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUS13_RS00660 147601..147828 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUS13_RS00665 148004..148624 - 621 WP_003101226.1 hypothetical protein -
HUS13_RS00670 148725..149225 + 501 WP_003083778.1 LEA type 2 family protein -
HUS13_RS00675 149298..149639 + 342 WP_014603467.1 alkylphosphonate utilization protein -
HUS13_RS00680 149721..151148 - 1428 WP_003083784.1 GABA permease -
HUS13_RS00685 151317..152810 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T160517 WP_003083773.1 NZ_CP054845:c147604-147323 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T160517 NZ_CP070549:3087264-3087581 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT160517 WP_003083775.1 NZ_CP054845:c147828-147601 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT160517 NZ_CP070549:3087634-3087930 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References