160508

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 160690..161195 Replicon chromosome
Accession NZ_CP054844
Organism Pseudomonas aeruginosa strain SE5357

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUS11_RS00740 Protein ID WP_003083773.1
Coordinates 160690..160971 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUS11_RS00745 Protein ID WP_003083775.1
Coordinates 160968..161195 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS11_RS00715 155941..157290 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HUS11_RS00720 157339..158025 + 687 WP_003083762.1 FadR family transcriptional regulator -
HUS11_RS00725 158126..158860 + 735 WP_003117208.1 GntR family transcriptional regulator -
HUS11_RS00730 159064..159450 + 387 WP_014602345.1 aegerolysin family protein -
HUS11_RS00735 159482..160390 - 909 WP_010793581.1 LysR family transcriptional regulator -
HUS11_RS00740 160690..160971 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUS11_RS00745 160968..161195 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUS11_RS00750 161371..161991 - 621 WP_003101226.1 hypothetical protein -
HUS11_RS00755 162092..162592 + 501 WP_003101228.1 LEA type 2 family protein -
HUS11_RS00760 162665..163006 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HUS11_RS00765 163088..164515 - 1428 WP_003083784.1 GABA permease -
HUS11_RS00770 164684..166177 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T160508 WP_003083773.1 NZ_CP054844:c160971-160690 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T160508 NZ_CP070545:99058-99474 [Citrobacter freundii]
GTGAACAAGACCTATATGCTGGACACCAACATCTGCTCATTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
TGAGCAGGCGGTGCTGCGTAACCAGCGCATCGTTGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCACATCGAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCGCTGCGCATGGCCGGCACGCCGATCGGCCCGAACGACACGGCTATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTAGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT160508 WP_003083775.1 NZ_CP054844:c161195-160968 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT160508 NZ_CP070545:98831-99061 [Citrobacter freundii]
ATGAGAACCGTATCTATTTTCAAAAATGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References