Detailed information of TA system TA160506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4776788..4778046
• Replicon: chromosome
• Accession: NZ_CP054843
• Organism: Pseudomonas aeruginosa strain SE5352

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: HUS10_RS22230
• Protein ID: WP_003086331.1
• Coordinates: 4776788..4777543 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: HUS10_RS22235
• Protein ID: WP_003086329.1
• Coordinates: 4777678..4778046 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUS10_RS22220	4771959..4774502	+	2544	WP_003086335.1	acyl-homoserine-lactone acylase QuiP	-
HUS10_RS22225	4774657..4776018	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
HUS10_RS22230	4776788..4777543	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
HUS10_RS22235	4777678..4778046	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
HUS10_RS22240	4778119..4779405	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
HUS10_RS22245	4779461..4781050	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
HUS10_RS22250	4781129..4781605	+	477	WP_003086322.1	hypothetical protein	-
HUS10_RS22255	4781608..4781883	-	276	WP_023098713.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T160506 WP_003086331.1 NZ_CP054843:c4777543-4776788 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T160506 NZ_CP070537:c1977161-1976679 [Morganella morganii]
TTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCATTGGCTGAAAACCCGCGCATTGCA
AAATCAGCAATCCGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAATGGCCTATTATGCATTATCGACAG
GCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAAATTCCGGTTATCCTGCCGGGACGT
CTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGATGCCGCACTGCGGGTCTTGCAGGC
GGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCAGACGTTTTTATGAGCATACCGGTT
TTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAGCTGGCAACCGGCATCTATTCTGAA
TAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT160506 WP_003086329.1 NZ_CP054843:c4778046-4777678 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT160506 NZ_CP070537:c1977496-1977188 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGGCGAAGGCGCCGTGGGAGAAGTAA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7