Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 4213671..4214713 | Replicon | chromosome |
| Accession | NZ_CP054843 | ||
| Organism | Pseudomonas aeruginosa strain SE5352 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | HUS10_RS19530 | Protein ID | WP_003153636.1 |
| Coordinates | 4213671..4214246 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | HUS10_RS19535 | Protein ID | WP_003050245.1 |
| Coordinates | 4214243..4214713 (-) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUS10_RS19505 | 4210109..4210834 | - | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
| HUS10_RS19510 | 4210873..4211775 | - | 903 | WP_003090158.1 | nucleotidyltransferase domain-containing protein | - |
| HUS10_RS19515 | 4211775..4212275 | - | 501 | WP_003090159.1 | hypothetical protein | - |
| HUS10_RS19520 | 4212272..4212742 | - | 471 | WP_063305693.1 | hypothetical protein | - |
| HUS10_RS19525 | 4212739..4213653 | - | 915 | WP_016852809.1 | AAA family ATPase | - |
| HUS10_RS19530 | 4213671..4214246 | - | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| HUS10_RS19535 | 4214243..4214713 | - | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HUS10_RS19540 | 4214917..4215300 | + | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| HUS10_RS19545 | 4215297..4215530 | + | 234 | WP_006226027.1 | TIGR03758 family integrating conjugative element protein | - |
| HUS10_RS19550 | 4215547..4215906 | + | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| HUS10_RS19555 | 4215918..4216316 | + | 399 | WP_003050133.1 | TIGR03750 family conjugal transfer protein | - |
| HUS10_RS19560 | 4216313..4217005 | + | 693 | WP_003090182.1 | TIGR03746 family integrating conjugative element protein | - |
| HUS10_RS19565 | 4217002..4217913 | + | 912 | WP_006226028.1 | TIGR03749 family integrating conjugative element protein | - |
| HUS10_RS19570 | 4217903..4219321 | + | 1419 | WP_006226029.1 | TIGR03752 family integrating conjugative element protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 4165275..4289288 | 124013 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T160505 WP_003153636.1 NZ_CP054843:c4214246-4213671 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T160505 NZ_CP070537:c390008-389631 [Morganella morganii]
ATGAAAACATTACCCGACACACACATACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCGTCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTTACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAACTACAGAACGATAAATGACATTACCCTGGGTAAACATCCGGGGGTGAAACAATGA
ATGAAAACATTACCCGACACACACATACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCGTCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTTACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAACTACAGAACGATAAATGACATTACCCTGGGTAAACATCCGGGGGTGAAACAATGA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT160505 WP_003050245.1 NZ_CP054843:c4214713-4214243 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT160505 NZ_CP070537:c390466-390098 [Morganella morganii]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGCGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGCACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGCGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGCACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|