Detailed information of TA system TA160504

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3264652..3265873
• Replicon: chromosome
• Accession: NZ_CP054843
• Organism: Pseudomonas aeruginosa strain SE5352

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: V6AG16
• Locus tag: HUS10_RS15575
• Protein ID: WP_003088107.1
• Coordinates: 3264652..3265230 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUS10_RS15580
• Protein ID: WP_003088112.1
• Coordinates: 3265319..3265873 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUS10_RS15560	3259928..3261205	+	1278	WP_003088104.1	TolC family protein	-
HUS10_RS15565	3261195..3263366	+	2172	WP_003088105.1	type I secretion system permease/ATPase	-
HUS10_RS15570	3263356..3264543	+	1188	WP_003088106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HUS10_RS15575	3264652..3265230	-	579	WP_003088107.1	HD domain-containing protein	Toxin
HUS10_RS15580	3265319..3265873	-	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
HUS10_RS15585	3266031..3268226	-	2196	WP_003088114.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HUS10_RS15590	3268231..3268692	-	462	WP_003088117.1	(2Fe-2S)-binding protein	-
HUS10_RS15595	3269023..3269346	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
HUS10_RS15600	3269359..3269757	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
HUS10_RS15605	3269754..3270305	-	552	WP_023098678.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-187)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21885.74 Da
• Isoelectric Point: 5.3655

>T160504 WP_003088107.1 NZ_CP054843:c3265230-3264652 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T160504 NZ_CP070534:c4719954-4719544 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT160504 WP_003088112.1 NZ_CP054843:c3265873-3265319 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT160504 NZ_CP070534:c4720201-4719935 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: V6AG16