Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 183620..184125 Replicon chromosome
Accession NZ_CP054843
Organism Pseudomonas aeruginosa strain SE5352

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUS10_RS00800 Protein ID WP_003083773.1
Coordinates 183620..183901 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUS10_RS00805 Protein ID WP_003083775.1
Coordinates 183898..184125 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS10_RS00775 178871..180220 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
HUS10_RS00780 180269..180955 + 687 WP_003083762.1 FadR family transcriptional regulator -
HUS10_RS00785 181056..181790 + 735 WP_003083764.1 GntR family transcriptional regulator -
HUS10_RS00790 181994..182380 + 387 WP_003083767.1 aegerolysin family protein -
HUS10_RS00795 182412..183320 - 909 WP_003083769.1 LysR family transcriptional regulator -
HUS10_RS00800 183620..183901 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUS10_RS00805 183898..184125 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUS10_RS00810 184301..184921 - 621 WP_003101226.1 hypothetical protein -
HUS10_RS00815 185022..185522 + 501 WP_003083778.1 LEA type 2 family protein -
HUS10_RS00820 185595..185936 + 342 WP_014603467.1 alkylphosphonate utilization protein -
HUS10_RS00825 186018..187445 - 1428 WP_003083784.1 GABA permease -
HUS10_RS00830 187614..189107 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T160502 WP_003083773.1 NZ_CP054843:c183901-183620 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T160502 NZ_CP070534:c3593567-3593464 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT160502 WP_003083775.1 NZ_CP054843:c184125-183898 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT160502 NZ_CP070534:3593457-3593660 [Enterobacter hormaechei]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTG
GTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References