Detailed information of TA system TA160500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT_toxin-BrnA
• Location: 1427290..1427845
• Replicon: chromosome
• Accession: NZ_CP054840
• Organism: Acidovorax antarcticus strain 16-35-5

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: HUK68_RS06800
• Protein ID: WP_175503514.1
• Coordinates: 1427573..1427845 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: HUK68_RS06795
• Protein ID: WP_175503513.1
• Coordinates: 1427290..1427592 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK68_RS06755	1422532..1424430	-	1899	WP_175503506.1	replication endonuclease	-
HUK68_RS06760	1424433..1424855	-	423	WP_175503507.1	hypothetical protein	-
HUK68_RS06765	1424852..1425010	-	159	WP_175503508.1	hypothetical protein	-
HUK68_RS06770	1425102..1425647	-	546	WP_175503509.1	ogr/Delta-like zinc finger family protein	-
HUK68_RS06775	1425658..1426116	-	459	WP_175503510.1	hypothetical protein	-
HUK68_RS06780	1426162..1426419	+	258	WP_175503511.1	hypothetical protein	-
HUK68_RS06785	1426627..1426962	+	336	WP_175503512.1	helix-turn-helix domain-containing protein	-
HUK68_RS06790	1427028..1427207	+	180	WP_175502327.1	hypothetical protein	-
HUK68_RS06795	1427290..1427592	-	303	WP_175503513.1	BrnA antitoxin family protein	Antitoxin
HUK68_RS06800	1427573..1427845	-	273	WP_175503514.1	BrnT family toxin	Toxin
HUK68_RS06805	1427944..1429095	-	1152	WP_175503515.1	late control protein	-
HUK68_RS06810	1429106..1429576	-	471	WP_175503258.1	phage tail protein	-
HUK68_RS06815	1429579..1432512	-	2934	WP_175503516.1	phage tail tape measure protein	-
HUK68_RS06820	1432555..1432722	-	168	WP_175503517.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (31-91)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10478.97 Da
• Isoelectric Point: 6.4641

>T160500 WP_175503514.1 NZ_CP054840:c1427845-1427573 [Acidovorax antarcticus]
MKTEFDAIKDAANQQKHGVSLSLASMIEWQDVLCFVDDRADYKEVREVGFAVIDQRLYVVVFVQRGDTMRIISLRKANKR
ELKHYEQASE

Nucleotide

• Length: 273 bp

>T160500 NZ_CP070534:2561382-2561903 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10899.52 Da
• Isoelectric Point: 10.9528

>AT160500 WP_175503513.1 NZ_CP054840:c1427592-1427290 [Acidovorax antarcticus]
MNKRLNKSGLIAPTDAEDAAINRGIAADPDTVEITAELAARMQPLRRRGRPAVERPKAPMTTRVDADVLDAIKHSGKGWQ
TRLNDVLREAVQKGKFKAAA

Nucleotide

• Length: 303 bp

>AT160500 NZ_CP070534:2561106-2561375 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA