Detailed information of TA system TA160499

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT_toxin-BrnA
• Location: 1128228..1128783
• Replicon: chromosome
• Accession: NZ_CP054840
• Organism: Acidovorax antarcticus strain 16-35-5

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: HUK68_RS05245
• Protein ID: WP_175503239.1
• Coordinates: 1128511..1128783 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: HUK68_RS05240
• Protein ID: WP_175503238.1
• Coordinates: 1128228..1128530 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK68_RS05215	1123314..1123967	+	654	WP_175503234.1	NAD(P)-dependent oxidoreductase	-
HUK68_RS05220	1124124..1125293	+	1170	WP_175503235.1	sugar transporter	-
HUK68_RS05225	1125535..1125753	+	219	WP_175503236.1	hypothetical protein	-
HUK68_RS05230	1125972..1127528	-	1557	WP_175503237.1	cache domain-containing protein	-
HUK68_RS05235	1127960..1128139	+	180	WP_175502326.1	hypothetical protein	-
HUK68_RS05240	1128228..1128530	-	303	WP_175503238.1	BrnA antitoxin family protein	Antitoxin
HUK68_RS05245	1128511..1128783	-	273	WP_175503239.1	BrnT family toxin	Toxin
HUK68_RS05250	1129329..1130360	-	1032	WP_175503240.1	integrase	-
HUK68_RS05255	1130378..1130587	-	210	WP_175503241.1	DUF4224 domain-containing protein	-
HUK68_RS05260	1130708..1131049	-	342	WP_175503242.1	hypothetical protein	-
HUK68_RS05265	1131046..1132707	-	1662	WP_175503243.1	DNA cytosine methyltransferase	-
HUK68_RS05270	1132715..1133230	-	516	WP_175503244.1	DUF4406 domain-containing protein	-
HUK68_RS05275	1133244..1133462	-	219	WP_175503245.1	hypothetical protein	-
HUK68_RS05280	1133455..1133667	-	213	WP_175503246.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (31-91)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10537.05 Da
• Isoelectric Point: 6.4641

>T160499 WP_175503239.1 NZ_CP054840:c1128783-1128511 [Acidovorax antarcticus]
MKTEFDAIKDAANQQKHGVSLSLASMIEWQDVLCFVDDRADYKEVREVGFAVIDWRLYVVVFVQRGDTMRIISLRKANKR
ELKHYEQASE

Nucleotide

• Length: 273 bp

>T160499 NZ_CP070534:c2451673-2451200 [Enterobacter hormaechei]
ATGATTTTTTATCGTCTGGTGACAGGACGTTTTGCCAGCGAAGCGTGGAGTGGCAGTGGTGCAAACCAGTATGGCGGACG
CTGGAATCATAAAGGCCATCCTGCCGTGTATGTCTCCACCTCCATCTCGCTGGCTTCACTGGAAATTCTGGTGCATGTCA
GAAAAGACACCGTGCTGAACCAGTACCAGCTTTTCAGCATTAATATCCCGGATGATCAGATTGATTACCTGGATAAAGCG
TGGCTGCCCGAGGACTGGCAGGAAAATCCGGCGCCGGTATCAACGATGGATCTGGGTACCGGTTGGTTGCAGGCTAACAG
CGCTCTCGCACTCATCTTACCCTCCTGCATCATTCCCTATGAAAACAACGCCATACTTAATCCATTGCATCCGGCATTCC
GCAAAGCACTTAATTCTGTTGAGTTACTGCCTTTTAATTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10935.60 Da
• Isoelectric Point: 11.1500

>AT160499 WP_175503238.1 NZ_CP054840:c1128530-1128228 [Acidovorax antarcticus]
MNKRLNKSGLIAPTDAEDAAINRGIAADPHTVEITAELAARMQPLRRRGRPAVERPKAPMTTRVDADVLEAIKHSGKGWQ
TRLNDVLREAVQKGKFKAAA

Nucleotide

• Length: 303 bp

>AT160499 NZ_CP070534:c2452113-2451670 [Enterobacter hormaechei]
ATGAGAACATGGGTTCCTGCGCAAAGGCCGGCTGATAACACGCTGTGGCGCTACGCCGGTTTACCTGCAAGCAGAGGCAT
GCGGCTGATTGAATATCTCAATCAAGGATTACCCGTCAGCGTCCTCGACAATATTCACGAGTGGACGGACATGTCGAAAG
CGGAGATTTTACGCGTCACGGGAATTAACGAGCGTAACGTTGCCCGCCGCAAAAGTACGGGCCGGACGCTGACGCCCGAC
GAGAGCGAACGTGTGGCGCGTTTCGTTCGGGTACTGGATGCGGCCGTCGATTATTTCGGCAGTAAAGAAGAGGCATGGAA
CTGGTTGCAGTTACCGGTACGTGGGCTTGGCAATGTTGCGCCTGTCGATCTGATTGCCACGGAAACCGGTGCGCTGGAAG
TTACCGATTTGATTGGTCGGCTGGAGCACGGAGTGTTCGCATGA