Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 902850..903379 Replicon chromosome
Accession NZ_CP054831
Organism Staphylococcus saprophyticus strain UTI-045

Toxin (Protein)


Gene name mazF Uniprot ID Q49Z22
Locus tag HSZ48_RS04375 Protein ID WP_011302703.1
Coordinates 903017..903379 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q49Z23
Locus tag HSZ48_RS04370 Protein ID WP_011302702.1
Coordinates 902850..903020 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ48_RS04345 898581..899060 + 480 WP_011302698.1 PH domain-containing protein -
HSZ48_RS04350 899053..900591 + 1539 WP_041784781.1 PH domain-containing protein -
HSZ48_RS04355 900584..901084 + 501 WP_011302700.1 PH domain-containing protein -
HSZ48_RS04360 901148..901498 + 351 WP_002482750.1 holo-ACP synthase -
HSZ48_RS04365 901614..902762 + 1149 WP_175267841.1 alanine racemase -
HSZ48_RS04370 902850..903020 + 171 WP_011302702.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HSZ48_RS04375 903017..903379 + 363 WP_011302703.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HSZ48_RS04380 903716..904717 + 1002 WP_011302704.1 PP2C family protein-serine/threonine phosphatase -
HSZ48_RS04385 904796..905122 + 327 WP_011302705.1 anti-sigma factor antagonist -
HSZ48_RS04390 905124..905606 + 483 WP_002482755.1 anti-sigma B factor RsbW -
HSZ48_RS04395 905581..906351 + 771 WP_002482756.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13482.70 Da        Isoelectric Point: 10.3173

>T160486 WP_011302703.1 NZ_CP054831:903017-903379 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKA

Download         Length: 363 bp

>T160486 NZ_CP070528:c2718685-2717363 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCTACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6332.00 Da        Isoelectric Point: 4.0121

>AT160486 WP_011302702.1 NZ_CP054831:902850-903020 [Staphylococcus saprophyticus]
MASFNQSRIHNIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT160486 NZ_CP070528:c2718951-2718685 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q49Z22

Antitoxin

Source ID Structure
AlphaFold DB Q49Z23

References