Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 891180..891694 Replicon chromosome
Accession NZ_CP054831
Organism Staphylococcus saprophyticus strain UTI-045

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag HSZ48_RS04315 Protein ID WP_002482741.1
Coordinates 891488..891694 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag HSZ48_RS04310 Protein ID WP_002482740.1
Coordinates 891180..891473 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ48_RS04285 886342..887133 + 792 WP_011302688.1 hydroxyethylthiazole kinase -
HSZ48_RS04290 887133..887771 + 639 WP_011302689.1 thiamine phosphate synthase -
HSZ48_RS04295 887859..888728 + 870 WP_011302690.1 membrane protein insertase YidC -
HSZ48_RS04300 888810..889484 - 675 WP_170178158.1 HD domain-containing protein -
HSZ48_RS04305 889553..891037 - 1485 WP_011302692.1 cardiolipin synthase -
HSZ48_RS04310 891180..891473 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
HSZ48_RS04315 891488..891694 + 207 WP_002482741.1 hypothetical protein Toxin
HSZ48_RS04320 891907..892047 + 141 WP_002482742.1 hypothetical protein -
HSZ48_RS04325 892340..893545 - 1206 WP_011302694.1 rod shape-determining protein RodA -
HSZ48_RS04330 893794..894864 + 1071 WP_011302695.1 D-alanine--D-alanine ligase -
HSZ48_RS04335 894877..896232 + 1356 WP_011302696.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T160485 WP_002482741.1 NZ_CP054831:891488-891694 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T160485 NZ_CP070528:1995722-1995824 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT160485 WP_002482740.1 NZ_CP054831:891180-891473 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT160485 NZ_CP070528:c1995831-1995686 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References