Detailed information of TA system TA160483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4538373..4539631
• Replicon: chromosome
• Accession: NZ_CP054794
• Organism: Pseudomonas aeruginosa strain A0002

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HUK78_RS21170
• Protein ID: WP_003123189.1
• Coordinates: 4538373..4539128 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: HUK78_RS21175
• Protein ID: WP_003086329.1
• Coordinates: 4539263..4539631 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK78_RS21160 (HUK78_21155)	4533546..4536089	+	2544	WP_003123188.1	acyl-homoserine-lactone acylase QuiP	-
HUK78_RS21165 (HUK78_21160)	4536244..4537605	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
HUK78_RS21170 (HUK78_21165)	4538373..4539128	-	756	WP_003123189.1	RES family NAD+ phosphorylase	Toxin
HUK78_RS21175 (HUK78_21170)	4539263..4539631	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
HUK78_RS21180 (HUK78_21175)	4539704..4540990	-	1287	WP_003123190.1	FAD-binding oxidoreductase	-
HUK78_RS21185 (HUK78_21180)	4541046..4542635	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
HUK78_RS21190 (HUK78_21185)	4542714..4543190	+	477	WP_003112531.1	hypothetical protein	-
HUK78_RS21195 (HUK78_21190)	4543193..4543468	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28267.46 Da
• Isoelectric Point: 8.3428

>T160483 WP_003123189.1 NZ_CP054794:c4539128-4538373 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQKLGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T160483 NZ_CP070528:811862-812272 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT160483 WP_003086329.1 NZ_CP054794:c4539631-4539263 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT160483 NZ_CP070528:811615-811881 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7