Detailed information of TA system TA160479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 141139..141644
• Replicon: chromosome
• Accession: NZ_CP054794
• Organism: Pseudomonas aeruginosa strain A0002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HUK78_RS00640
• Protein ID: WP_023518248.1
• Coordinates: 141139..141420 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: HUK78_RS00645
• Protein ID: WP_003083775.1
• Coordinates: 141417..141644 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK78_RS00615 (HUK78_00615)	136390..137739	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
HUK78_RS00620 (HUK78_00620)	137788..138474	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
HUK78_RS00625 (HUK78_00625)	138575..139309	+	735	WP_003117208.1	GntR family transcriptional regulator	-
HUK78_RS00630 (HUK78_00630)	139489..139899	+	411	WP_003101225.1	aegerolysin family protein	-
HUK78_RS00635 (HUK78_00635)	139931..140839	-	909	WP_003083769.1	LysR family transcriptional regulator	-
HUK78_RS00640 (HUK78_00640)	141139..141420	-	282	WP_023518248.1	type II toxin-antitoxin system toxin ParE	Toxin
HUK78_RS00645 (HUK78_00645)	141417..141644	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
HUK78_RS00650 (HUK78_00650)	141820..142440	-	621	WP_003101226.1	hypothetical protein	-
HUK78_RS00655 (HUK78_00655)	142541..143041	+	501	WP_003101228.1	LEA type 2 family protein	-
HUK78_RS00660 (HUK78_00660)	143114..143455	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
HUK78_RS00665 (HUK78_00665)	143537..144964	-	1428	WP_003083784.1	GABA permease	-
HUK78_RS00670 (HUK78_00670)	145133..146626	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10472.23 Da
• Isoelectric Point: 10.0435

>T160479 WP_023518248.1 NZ_CP054794:c141420-141139 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRIEITP

Nucleotide

• Length: 282 bp

>T160479 NZ_CP070524:c3761979-3761497 [Morganella morganii]
TTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCATTGGCTGAAAACCCGCGCATTGCA
AAATCAGCAATCCGGAGCCTCACGGACATTTGTCGTCTGCCACCATAACCGGATAATGGCCTATTATGCATTATCGACAG
GTGTGATTACCTGTTCACAGGCGGCGGGTCGTTTCAGGCGTAATATGCCCCCGGAAATTCCGGTTATCCTGCCGGGACGT
CTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGATGCCGCACTGCGGGTCTTGCAGGC
GGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCAGACGTTTTTATGAGCATACCGGTT
TTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAGCTGGCAACCGGTATCTATTCTGAA
TAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT160479 WP_003083775.1 NZ_CP054794:c141644-141417 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT160479 NZ_CP070524:c3762314-3762006 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9