Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141798..142303 Replicon chromosome
Accession NZ_CP054793
Organism Pseudomonas aeruginosa strain SE5452

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUK77_RS00645 Protein ID WP_003083773.1
Coordinates 141798..142079 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUK77_RS00650 Protein ID WP_003083775.1
Coordinates 142076..142303 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK77_RS00620 (HUK77_00620) 137049..138398 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HUK77_RS00625 (HUK77_00625) 138447..139133 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
HUK77_RS00630 (HUK77_00630) 139234..139968 + 735 WP_003117208.1 GntR family transcriptional regulator -
HUK77_RS00635 (HUK77_00635) 140148..140558 + 411 WP_003101225.1 aegerolysin family protein -
HUK77_RS00640 (HUK77_00640) 140590..141498 - 909 WP_003083769.1 LysR family transcriptional regulator -
HUK77_RS00645 (HUK77_00645) 141798..142079 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUK77_RS00650 (HUK77_00650) 142076..142303 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUK77_RS00655 (HUK77_00655) 142479..143099 - 621 WP_003101226.1 hypothetical protein -
HUK77_RS00660 (HUK77_00660) 143200..143700 + 501 WP_003112629.1 LEA type 2 family protein -
HUK77_RS00665 (HUK77_00665) 143773..144114 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
HUK77_RS00670 (HUK77_00670) 144196..145623 - 1428 WP_003083784.1 GABA permease -
HUK77_RS00675 (HUK77_00675) 145792..147285 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T160472 WP_003083773.1 NZ_CP054793:c142079-141798 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T160472 NZ_CP070520:4099382-4099723 [Klebsiella aerogenes]
ATGAAAACTCTACCTGCAATAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCTGTGGCAGTCTGGCAAATGTTACTGAC
ACGCCTGTTGGAACAGCACTATGGTCTTACACTAAACGATACGCAGTTCAGTGATGAAACGGTTATACAGGAACATATCG
ATGCCGGTATTACTCTGGCTAATGCCGTTAACTTTTTGGTGGAGAAATATGAATTGGTTCGTATCGATCGCAAAGGACTT
AGCTGGCAAGAGCAGTCCCCATATCTTCGGGCTGTAGATATTCTCCGGGCACGACAGGCAACTGGCTTGTTGCGACGAAA
CAGTAGTAACTCCGGATTGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT160472 WP_003083775.1 NZ_CP054793:c142303-142076 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT160472 NZ_CP070520:4099020-4099361 [Klebsiella aerogenes]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTAAAATGGGGACTGAATCGTAATGTGACACCTTGCTTTGGTGCTCG
TCTAGTACAGGAGGGAAACCGGTTGTACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAATAATGCAGAATCTT
TGAAGTTGGATGAAGTACTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAACCCTCGCCAT
GCCCACTGTGTCACTCTGTACCACAATTGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGC
CATTTATCCCACACAACGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6XRW


Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References