Detailed information of TA system TA160468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3528133..3529354
• Replicon: chromosome
• Accession: NZ_CP054792
• Organism: Pseudomonas aeruginosa strain SE5431

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: HUK75_RS16365
• Protein ID: WP_003110488.1
• Coordinates: 3528776..3529354 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUK75_RS16360
• Protein ID: WP_003132728.1
• Coordinates: 3528133..3528687 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK75_RS16335 (HUK75_16310)	3523701..3524252	+	552	WP_003132721.1	XRE family transcriptional regulator	-
HUK75_RS16340 (HUK75_16315)	3524249..3524647	-	399	WP_033990114.1	NADH-quinone oxidoreductase subunit A	-
HUK75_RS16345 (HUK75_16320)	3524660..3524983	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
HUK75_RS16350 (HUK75_16325)	3525314..3525775	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
HUK75_RS16355 (HUK75_16330)	3525780..3527975	+	2196	WP_033990116.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HUK75_RS16360 (HUK75_16335)	3528133..3528687	+	555	WP_003132728.1	helix-turn-helix transcriptional regulator	Antitoxin
HUK75_RS16365 (HUK75_16340)	3528776..3529354	+	579	WP_003110488.1	HD domain-containing protein	Toxin
HUK75_RS16370 (HUK75_16345)	3529463..3530650	-	1188	WP_003088106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HUK75_RS16375 (HUK75_16350)	3530640..3532811	-	2172	WP_033990118.1	type I secretion system permease/ATPase	-
HUK75_RS16380 (HUK75_16355)	3532801..3534078	-	1278	WP_003088104.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T160468 WP_003110488.1 NZ_CP054792:3528776-3529354 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T160468 NZ_CP070520:c934955-934470 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCTCAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACACGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTATCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTCTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTTCGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCCACCACCCAGGAACGCACACTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20470.63 Da
• Isoelectric Point: 8.1590

>AT160468 WP_003132728.1 NZ_CP054792:3528133-3528687 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT160468 NZ_CP070520:c935209-934943 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCCTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACCCCGCTCTCGACAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4