Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4825969..4826609 Replicon chromosome
Accession NZ_CP054790
Organism Pseudomonas aeruginosa strain SE5418

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUK71_RS22925 Protein ID WP_003105740.1
Coordinates 4825969..4826379 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HUK71_RS22930 Protein ID WP_031634724.1
Coordinates 4826379..4826609 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK71_RS22885 4821321..4822034 + 714 WP_235179931.1 hypothetical protein -
HUK71_RS22890 (HUK71_22885) 4822191..4822919 + 729 WP_025324783.1 TIGR03761 family integrating conjugative element protein -
HUK71_RS22895 (HUK71_22890) 4822925..4823473 + 549 WP_034038747.1 DUF3158 family protein -
HUK71_RS22900 (HUK71_22895) 4823521..4824351 + 831 WP_023132184.1 Rha family transcriptional regulator -
HUK71_RS22905 (HUK71_22900) 4824381..4824869 + 489 WP_034038749.1 single-stranded DNA-binding protein -
HUK71_RS22910 (HUK71_22905) 4825007..4825204 + 198 WP_003109353.1 CrpP family ICE-associated protein -
HUK71_RS22915 (HUK71_22910) 4825270..4825488 - 219 WP_003105747.1 hypothetical protein -
HUK71_RS22920 (HUK71_22915) 4825687..4825947 - 261 WP_003105742.1 hypothetical protein -
HUK71_RS22925 (HUK71_22920) 4825969..4826379 - 411 WP_003105740.1 tRNA(fMet)-specific endonuclease VapC Toxin
HUK71_RS22930 (HUK71_22925) 4826379..4826609 - 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HUK71_RS22935 (HUK71_22930) 4826927..4828846 + 1920 WP_034038751.1 type I DNA topoisomerase -
HUK71_RS22940 (HUK71_22935) 4828855..4829607 + 753 WP_034038753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4797903..4833816 35913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15450.81 Da        Isoelectric Point: 7.3233

>T160457 WP_003105740.1 NZ_CP054790:c4826379-4825969 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVVPIV

Download         Length: 411 bp

>T160457 NZ_CP070508:62441-62716 [Serratia ureilytica]
ATGGAGTTAAAATGGACGAGTAAGGCGCTACCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGATGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT160457 WP_031634724.1 NZ_CP054790:c4826609-4826379 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp

>AT160457 NZ_CP070508:62181-62441 [Serratia ureilytica]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCCGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCGGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References