Detailed information of TA system TA160455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3770625..3771846
• Replicon: chromosome
• Accession: NZ_CP054790
• Organism: Pseudomonas aeruginosa strain SE5418

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: HUK71_RS17865
• Protein ID: WP_003102740.1
• Coordinates: 3771268..3771846 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUK71_RS17860
• Protein ID: WP_003088112.1
• Coordinates: 3770625..3771179 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK71_RS17835 (HUK71_17845)	3766193..3766744	+	552	WP_004343115.1	XRE family transcriptional regulator	-
HUK71_RS17840 (HUK71_17850)	3766741..3767139	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
HUK71_RS17845 (HUK71_17855)	3767152..3767475	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
HUK71_RS17850 (HUK71_17860)	3767806..3768267	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
HUK71_RS17855 (HUK71_17865)	3768272..3770467	+	2196	WP_010794059.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HUK71_RS17860 (HUK71_17870)	3770625..3771179	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
HUK71_RS17865 (HUK71_17875)	3771268..3771846	+	579	WP_003102740.1	HD domain-containing protein	Toxin
HUK71_RS17870 (HUK71_17880)	3771955..3773142	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HUK71_RS17875 (HUK71_17885)	3773132..3775303	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
HUK71_RS17880 (HUK71_17890)	3775293..3776570	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T160455 WP_003102740.1 NZ_CP054790:3771268-3771846 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T160455 NZ_CP070507:93316-93693 [Pseudomonas sp. SDM007]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTA
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT160455 WP_003088112.1 NZ_CP054790:3770625-3771179 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT160455 NZ_CP070507:93674-94009 [Pseudomonas sp. SDM007]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07