Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1963053..1964561 Replicon chromosome
Accession NZ_CP054790
Organism Pseudomonas aeruginosa strain SE5418

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag HUK71_RS09485 Protein ID WP_003119682.1
Coordinates 1963053..1963640 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag HUK71_RS09490 Protein ID WP_003091607.1
Coordinates 1963707..1964561 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK71_RS09480 (HUK71_09475) 1959308..1962787 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
HUK71_RS09485 (HUK71_09480) 1963053..1963640 + 588 WP_003119682.1 GNAT family protein Toxin
HUK71_RS09490 (HUK71_09485) 1963707..1964561 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
HUK71_RS09495 (HUK71_09490) 1964658..1966823 + 2166 WP_010793245.1 TonB-dependent receptor family protein -
HUK71_RS09500 (HUK71_09495) 1966998..1968872 + 1875 WP_010793244.1 MFS transporter -
HUK71_RS09505 (HUK71_09500) 1968933..1969142 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T160454 WP_003119682.1 NZ_CP054790:1963053-1963640 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T160454 NZ_CP070507:c38856-38554 [Pseudomonas sp. SDM007]
ATGAAGACAATTAAACAAACCGCCACGTACAGGAACTGGGAACGCAAGCTGCGAGACAAGCAGGCCAAAGCCATCATCGC
TGCGCGAGTCTTCCGCGTTGCAAATGGTCTGCTTGGGGACGTTCAACCAGTGGGCCAGGGGATCAGCGAACTGCGCATCC
ATCACGGCCCCGGCTACCGGGTGTATTTTCAGCAGCGCGGTAACCAACTGGTCCTGTTGCTGTGTGGTGGGGACAAGAGC
AGCCAAGCGCGGGATATCGAAACCGCTAAAGCGTTGGCCAGCCAGTGGAGTGACGATGAATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT160454 WP_003091607.1 NZ_CP054790:1963707-1964561 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT160454 NZ_CP070507:c38557-38258 [Pseudomonas sp. SDM007]
ATGAAAGAACAATTTTACGACTACGACCCCGCTGATGCGTTGACTGATGCGGAGTCCATCGCGGTATTCATGGAGGACGC
ATTCGAAACGGGCGATGCGGCCTATATCGCAAAATGCCTGGGTGTCGTAGCCCGCGCCAAAGGGATGACCGCCCTTGCCA
ATGAATCTGGCCTTTCCCGCGAACACCTCTACCGGTCGTTCTCGGACAAGGGCAACCCGACTTTGAAAACCCTGCTGGCC
GTAATGCGTGCCGTTGGCCTGGATCTTACGACCCGCAAGCACGTTGAGCCGGTACACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References